A6K5R6 · A6K5R6_RAT
- ProteinPolycystin-2
- GenePkd2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids966 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePolycystin-2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6K5R6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Cell projection, cilium membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 222-240 | Helical | ||||
Sequence: LVTYLFFLILLCILTYGMM | ||||||
Transmembrane | 419-441 | Helical | ||||
Sequence: AAFIDFSVYNANINLFCVVRLLV | ||||||
Transmembrane | 461-486 | Helical | ||||
Sequence: IRYVTAFDFFLAACEIIFCFFILYYV | ||||||
Transmembrane | 507-525 | Helical | ||||
Sequence: CLDVVIVVLSVVAMMINIY | ||||||
Transmembrane | 554-575 | Helical | ||||
Sequence: IQFNNIAAVMVFLVWIKLFKFI | ||||||
Transmembrane | 595-617 | Helical | ||||
Sequence: LFGFTIMFFIIFLAYAQLAYLVF | ||||||
Transmembrane | 657-678 | Helical | ||||
Sequence: LYFTTFVFFMFFILLNMFLAII |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 329↔342 | |||||
Sequence: CSIPQDLRDEIKEC |
Keywords
- PTM
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-179 | Disordered | ||||
Sequence: MVNSSRVQPQPPGDPGRSPAPRASGPGRLLAGGAGLAVPGGLREQRGLEIEMERIRQAAARDPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVEGEEGGMVVEMDVEWRPGSRRPASSSAVSSAGARGRGLGSYRGAAYPSGRRRRLEDQGAPCPSPAGGGDPLHRHLPLD | ||||||
Compositional bias | 90-109 | Acidic residues | ||||
Sequence: FEAEEDDDDDEVEGEEGGMV | ||||||
Domain | 748-783 | EF-hand | ||||
Sequence: HTDAEIEAIFTKYDQDGDQELTEREHQQMRDDLERE | ||||||
Region | 787-828 | Disordered | ||||
Sequence: LDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDSGHSSRRRGSI | ||||||
Region | 912-966 | Disordered | ||||
Sequence: ERWESDDAASQSGHGLGTQVGLGGQSHPRSSRPPSSQSAEGLEGGGGNGSTNAHA | ||||||
Compositional bias | 922-966 | Polar residues | ||||
Sequence: QSGHGLGTQVGLGGQSHPRSSRPPSSQSAEGLEGGGGNGSTNAHA |
Sequence similarities
Belongs to the polycystin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length966
- Mass (Da)109,093
- Last updated2023-06-28 v1
- Checksum3F4EFB2EF8C64AA7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 90-109 | Acidic residues | ||||
Sequence: FEAEEDDDDDEVEGEEGGMV | ||||||
Compositional bias | 922-966 | Polar residues | ||||
Sequence: QSGHGLGTQVGLGGQSHPRSSRPPSSQSAEGLEGGGGNGSTNAHA |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH474022 EMBL· GenBank· DDBJ | EDL99486.1 EMBL· GenBank· DDBJ | Genomic DNA |