A6K5R6 · A6K5R6_RAT

Function

Features

Showing features for binding site.

1966100200300400500600700800900
TypeIDPosition(s)Description
Binding site761Ca2+ (UniProtKB | ChEBI)
Binding site763Ca2+ (UniProtKB | ChEBI)
Binding site765Ca2+ (UniProtKB | ChEBI)
Binding site767Ca2+ (UniProtKB | ChEBI)
Binding site772Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasal cortex
Cellular Componentbasal plasma membrane
Cellular Componentcation channel complex
Cellular Componentcell-cell junction
Cellular Componentciliary basal body
Cellular Componentciliary membrane
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of endoplasmic reticulum membrane
Cellular Componentcytoplasmic vesicle membrane
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular exosome
Cellular ComponentGolgi apparatus
Cellular Componentlamellipodium
Cellular Componentlumenal side of endoplasmic reticulum membrane
Cellular Componentmembrane
Cellular Componentmigrasome
Cellular Componentmitotic spindle
Cellular Componentmotile cilium
Cellular Componentnon-motile cilium
Cellular Componentplasma membrane
Cellular Componentpolycystin complex
Molecular Functionactinin binding
Molecular Functionalpha-actinin binding
Molecular FunctionATPase binding
Molecular Functioncalcium channel activity
Molecular Functioncalcium ion binding
Molecular Functioncalcium-induced calcium release activity
Molecular Functionchannel activity
Molecular Functioncytoskeletal protein binding
Molecular FunctionHLH domain binding
Molecular Functionidentical protein binding
Molecular Functionmonoatomic cation channel activity
Molecular Functionmuscle alpha-actinin binding
Molecular Functionoutward rectifier potassium channel activity
Molecular Functionphosphoprotein binding
Molecular Functionpotassium channel activity
Molecular Functionprotein homodimerization activity
Molecular Functionsignaling receptor binding
Molecular Functiontranscription regulator inhibitor activity
Molecular Functiontransmembrane transporter binding
Molecular Functionvoltage-gated calcium channel activity
Molecular Functionvoltage-gated monoatomic cation channel activity
Molecular Functionvoltage-gated monoatomic ion channel activity
Molecular Functionvoltage-gated potassium channel activity
Molecular Functionvoltage-gated sodium channel activity
Biological Processaorta development
Biological Processbranching involved in ureteric bud morphogenesis
Biological Processcalcium ion transmembrane transport
Biological Processcalcium ion transport
Biological Processcell surface receptor signaling pathway
Biological Processcell surface receptor signaling pathway via JAK-STAT
Biological Processcellular response to calcium ion
Biological Processcellular response to cAMP
Biological Processcellular response to fluid shear stress
Biological Processcellular response to hydrostatic pressure
Biological Processcellular response to osmotic stress
Biological Processcilium organization
Biological Processdetection of mechanical stimulus
Biological Processdetection of nodal flow
Biological Processdetermination of left/right symmetry
Biological Processdetermination of liver left/right asymmetry
Biological Processembryonic placenta development
Biological Processestablishment of localization in cell
Biological Processheart development
Biological Processheart looping
Biological Processinorganic cation transmembrane transport
Biological Processintracellular calcium ion homeostasis
Biological Processkidney development
Biological Processliver development
Biological Processmesonephric duct development
Biological Processmesonephric tubule development
Biological Processmetanephric ascending thin limb development
Biological Processmetanephric cortex development
Biological Processmetanephric cortical collecting duct development
Biological Processmetanephric distal tubule development
Biological Processmetanephric mesenchyme development
Biological Processmetanephric part of ureteric bud development
Biological Processmetanephric S-shaped body morphogenesis
Biological Processmetanephric smooth muscle tissue development
Biological Processnegative regulation of G1/S transition of mitotic cell cycle
Biological Processneural tube development
Biological Processplacenta blood vessel development
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of nitric oxide biosynthetic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpotassium ion transmembrane transport
Biological Processprotein heterotetramerization
Biological Processprotein homotetramerization
Biological Processprotein tetramerization
Biological Processregulation of calcium ion import
Biological Processregulation of cell cycle
Biological Processregulation of cell population proliferation
Biological Processrelease of sequestered calcium ion into cytosol
Biological Processrenal artery morphogenesis
Biological Processrenal tubule morphogenesis
Biological Processsodium ion transmembrane transport
Biological Processspinal cord development
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polycystin-2

Gene names

    • Name
      Pkd2
    • Synonyms
      RGD1559992_predicted
    • ORF names
      rCG_37877

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6K5R6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane222-240Helical
Transmembrane419-441Helical
Transmembrane461-486Helical
Transmembrane507-525Helical
Transmembrane554-575Helical
Transmembrane595-617Helical
Transmembrane657-678Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond329↔342

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-179Disordered
Compositional bias90-109Acidic residues
Domain748-783EF-hand
Region787-828Disordered
Region912-966Disordered
Compositional bias922-966Polar residues

Sequence similarities

Belongs to the polycystin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    966
  • Mass (Da)
    109,093
  • Last updated
    2023-06-28 v1
  • Checksum
    3F4EFB2EF8C64AA7
MVNSSRVQPQPPGDPGRSPAPRASGPGRLLAGGAGLAVPGGLREQRGLEIEMERIRQAAARDPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVEGEEGGMVVEMDVEWRPGSRRPASSSAVSSAGARGRGLGSYRGAAYPSGRRRRLEDQGAPCPSPAGGGDPLHRHLPLDGQPPRVAWAERLVRGLRGLWGTRLMEESNANREKYLRSVLRELVTYLFFLILLCILTYGMMSSNVYYYTRTLSQLFIDTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGLYWKAQSSNHTQADNRSFIFYENLLLGVPRLRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLVEFPATGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFILYYVVEEILEIRIHRLNYFRSFWNCLDVVIVVLSVVAMMINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNNIAAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQMRDDLEREREDLDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKVKRREVLGRLLDGVAEDARLGRDSEIHREQMERLVREELERWESDDAASQSGHGLGTQVGLGGQSHPRSSRPPSSQSAEGLEGGGGNGSTNAHA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias90-109Acidic residues
Compositional bias922-966Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH474022
EMBL· GenBank· DDBJ
EDL99486.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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