A6K108 · A6K108_RAT
- ProteinPhosphodiesterase
- GenePde1c
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids633 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 228 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 228-232 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNLMH | ||||||
Binding site | 232 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 268 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 269 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 269 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 269 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 376 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 376 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 427 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | neuronal cell body | |
Molecular Function | calmodulin binding | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6K108
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for coiled coil, domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 34-64 | |||||
Sequence: LRKYKKTSQRLRSLVKQLERGEASVVDLKKN | ||||||
Domain | 151-528 | PDEase | ||||
Sequence: VGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSEGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKE | ||||||
Compositional bias | 453-495 | Polar residues | ||||
Sequence: LIDETSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSEGSAPIN | ||||||
Region | 453-497 | Disordered | ||||
Sequence: LIDETSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSEGSAPINNS | ||||||
Compositional bias | 524-553 | Basic and acidic residues | ||||
Sequence: KVPKEEKAKKEAEEKARLAAEEKQKEMEAK | ||||||
Region | 524-633 | Disordered | ||||
Sequence: KVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRTSKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKADDPEE | ||||||
Compositional bias | 571-585 | Polar residues | ||||
Sequence: ETKGQVNGTRTSKGD | ||||||
Compositional bias | 586-633 | Basic and acidic residues | ||||
Sequence: NPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKADDPEE |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length633
- Mass (Da)71,932
- Last updated2023-06-28 v1
- Checksum5E0D23A23C962DFB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 453-495 | Polar residues | ||||
Sequence: LIDETSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSEGSAPIN | ||||||
Compositional bias | 524-553 | Basic and acidic residues | ||||
Sequence: KVPKEEKAKKEAEEKARLAAEEKQKEMEAK | ||||||
Compositional bias | 571-585 | Polar residues | ||||
Sequence: ETKGQVNGTRTSKGD | ||||||
Compositional bias | 586-633 | Basic and acidic residues | ||||
Sequence: NPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKADDPEE |