A6JTR7 · A6JTR7_RAT

  • Protein
    Rap guanine nucleotide exchange factor (GEF) 1, isoform CRA_c
  • Gene
    Rapgef1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentearly endosome
Cellular Componentperinuclear region of cytoplasm
Cellular Componentphagocytic vesicle membrane
Cellular Componentplasma membrane
Cellular Componentprotein-containing complex
Molecular Functionguanyl-nucleotide exchange factor activity
Biological Processblood vessel development
Biological Processcanonical Wnt signaling pathway
Biological Processcell-cell adhesion
Biological Processcellular response to cAMP
Biological Processcellular response to nerve growth factor stimulus
Biological ProcessERK1 and ERK2 cascade
Biological Processestablishment of endothelial barrier
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of neural precursor cell proliferation
Biological Processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processnegative regulation of Ras protein signal transduction
Biological Processnerve growth factor signaling pathway
Biological Processneural precursor cell proliferation
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processplatelet-derived growth factor receptor signaling pathway
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of Fc receptor mediated stimulatory signaling pathway
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of phagocytosis
Biological ProcessRap protein signal transduction
Biological ProcessRas protein signal transduction
Biological Processregulation of cell junction assembly
Biological Processregulation of JNK cascade

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Rap guanine nucleotide exchange factor (GEF) 1, isoform CRA_c

Gene names

    • Name
      Rapgef1
    • ORF names
      rCG_45755

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BN
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6JTR7

Proteomes

Organism-specific databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-38Disordered
Region191-218Disordered
Region233-283Disordered
Region317-363Disordered
Compositional bias328-363Polar residues
Region383-408Disordered
Region421-456Disordered
Region502-523Disordered
Region574-644Disordered
Domain663-728N-terminal Ras-GEF

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    728
  • Mass (Da)
    80,191
  • Last updated
    2023-06-28 v1
  • Checksum
    48711CF3FCC7C450
MKLMDKFHSPKIKRTPSKKGKPAEVSKTPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTEREMEILNKTSVSPSTELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRAVSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQTPPQAACNLSPLPESMGESGPPFVGYSFQLPLGSCLQQDGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEDDLQNPAQPVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPPKQRQLEPPSGKDGHPRDLSVSSASGKDSRENGERSPKSLDALESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLHSRTRSSLPLLTHSRSE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias328-363Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH474001
EMBL· GenBank· DDBJ
EDL93381.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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