A6JT40 · A6JT40_RAT
- ProteinGlutamate receptor
- GeneGrin1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids959 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 537 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 539 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 544 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 685 | Crucial to convey clamshell closure to channel opening | |||
Binding site | 709 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 715 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 753 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 799 | Interaction with the cone snail toxin Con-ikot-ikot | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | NMDA selective glutamate receptor complex | |
Cellular Component | postsynaptic membrane | |
Molecular Function | ligand-gated monoatomic ion channel activity | |
Molecular Function | signaling receptor activity | |
Biological Process | ionotropic glutamate receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGlutamate receptor
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6JT40
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 583-601 | Helical | |||
Transmembrane | 656-678 | Helical | |||
Transmembrane | 834-858 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5039961491 | 21-959 | Glutamate receptor | ||
Disulfide bond | 765↔819 | ||||
Keywords
- PTM
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 454-816 | Ionotropic glutamate receptor C-terminal | |||
Domain | 460-528 | Ionotropic glutamate receptor L-glutamate and glycine-binding | |||
Region | 910-959 | Disordered | |||
Compositional bias | 938-959 | Basic and acidic residues | |||
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length959
- Mass (Da)108,045
- Last updated2023-06-28 v1
- ChecksumD965531F6C38EDDD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 938-959 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH474001 EMBL· GenBank· DDBJ | EDL93608.1 EMBL· GenBank· DDBJ | Genomic DNA |