A6JT40 · A6JT40_RAT

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for binding site, site.

1959100200300400500600700800900
Type
IDPosition(s)Description
Binding site537L-glutamate (UniProtKB | ChEBI)
Binding site539L-glutamate (UniProtKB | ChEBI)
Binding site544L-glutamate (UniProtKB | ChEBI)
Site685Crucial to convey clamshell closure to channel opening
Binding site709L-glutamate (UniProtKB | ChEBI)
Site715Interaction with the cone snail toxin Con-ikot-ikot
Binding site753L-glutamate (UniProtKB | ChEBI)
Site799Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular ComponentNMDA selective glutamate receptor complex
Cellular Componentpostsynaptic membrane
Molecular Functionligand-gated monoatomic ion channel activity
Molecular Functionsignaling receptor activity
Biological Processionotropic glutamate receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      Grin1
    • ORF names
      rCG_45539

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BN
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6JT40

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Postsynaptic cell membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane583-601Helical
Transmembrane656-678Helical
Transmembrane834-858Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_503996149121-959Glutamate receptor
Disulfide bond765↔819

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain454-816Ionotropic glutamate receptor C-terminal
Domain460-528Ionotropic glutamate receptor L-glutamate and glycine-binding
Region910-959Disordered
Compositional bias938-959Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    959
  • Mass (Da)
    108,045
  • Last updated
    2023-06-28 v1
  • Checksum
    D965531F6C38EDDD
MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias938-959Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH474001
EMBL· GenBank· DDBJ
EDL93608.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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