A6JJ35 · A6JJ35_RAT

  • Protein
    Platelet-activating factor acetylhydrolase
  • Gene
    Pla2g7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Catalytic activity

  • 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ + pentanoate
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ + propanoate
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.47 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site272Nucleophile
Active site295Charge relay system
Active site350Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componenthigh-density lipoprotein particle
Cellular Componentlow-density lipoprotein particle
Molecular Function1-alkyl-2-acetylglycerophosphocholine esterase activity
Molecular Functioncalcium-independent phospholipase A2 activity
Molecular Functionphospholipid binding
Biological Processlipid oxidation
Biological Processlow-density lipoprotein particle remodeling
Biological Processphosphatidylcholine catabolic process
Biological Processplasma lipoprotein particle oxidation
Biological Processplatelet activating factor catabolic process
Biological Processplatelet activating factor metabolic process
Biological Processpositive regulation of monocyte chemotaxis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-activating factor acetylhydrolase
  • EC number

Gene names

    • Name
      Pla2g7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6JJ35
  • Secondary accessions
    • Q5M7T7

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_504245035722-440Platelet-activating factor acetylhydrolase

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    440
  • Mass (Da)
    49,491
  • Last updated
    2023-06-28 v1
  • Checksum
    F8F8497F100D2FFE
MVPLKLRVLFCLLCCLPRVHPLYWQDPSFFDFRPSVMFHKLQSVMSAVSAGRCKIPKGNGSYPVGCTDMMFGYGNESIFLRLYYPAQDQGPHDTVWVPNIEYFWGLSKFLGTPTFVGNILRLLYGSLTAPASWNFPLRTGEKYPLIIFSHGLGAFRTIYSAIGAALASYGFIVATVEHRDGSASATYYFEDQAAAKMENRSWFYLKKIKQEESERARKEQVRQRAKECSKALSAILDIEHGNPKENVLGLPFDMKQLKDSIDETKIAVMGHSFGGATVFQALSEDQRFRCGIALDPWMFPVSEELYSRVPQPLFFINSAEFQTPKDIAKMKNFYQPDKERKMITIKGSVHQNFADGTFVTGKIIGNKLSLKGDIDSRVAIDLTNKASLAFLQKHLGLHKDFDQWDCLVEGENENLIPGSPFDVVTQSPALQSSPGSHNQN

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GE94A0A8I6GE94_RATPla2g7410
A0A8I5Y241A0A8I5Y241_RATPla2g7418

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC088457
EMBL· GenBank· DDBJ
AAH88457.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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