A6JHL1 · A6JHL1_RAT

  • Protein
    Elongation of very long chain fatty acids protein 3
  • Gene
    Elovl3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Lipid metabolism; polyunsaturated fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid elongase activity
Biological Processfatty acid elongation, monounsaturated fatty acid
Biological Processfatty acid elongation, polyunsaturated fatty acid
Biological Processfatty acid elongation, saturated fatty acid
Biological Processlong-chain fatty-acyl-CoA biosynthetic process
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processsphingolipid biosynthetic process
Biological Processunsaturated fatty acid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation of very long chain fatty acids protein 3
  • EC number
  • Alternative names
    • 3-keto acyl-CoA synthase ELOVL3
    • ELOVL fatty acid elongase 3
      (ELOVL FA elongase 3
      )
    • Very long chain 3-ketoacyl-CoA synthase 3
    • Very long chain 3-oxoacyl-CoA synthase 3

Gene names

    • Name
      Elovl3
    • Synonyms
      ELOVL3
      , Elovl3_predicted
    • ORF names
      rCG_57640

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6JHL1

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-56Helical
Transmembrane68-87Helical
Transmembrane116-137Helical
Transmembrane167-186Helical
Transmembrane198-224Helical
Transmembrane236-255Helical

Keywords

PTM/Processing

Post-translational modification

N-Glycosylated.

Keywords

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the ELO family. ELOVL3 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    32,139
  • Last updated
    2023-06-28 v1
  • Checksum
    FC9573303253B82C
MDTSMNFSRGLKTELIQPYDFEMSQDLRPFLEEYWVSSFFIVLVYLLLIIFGQNYMKTRKGFSLQRPLILWSFCLAIFSILGTLRMWKFMGTVLFTMGLKQTVCFTDYTNDAIVKFWSWVFLLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLLFTSFGYKNKVPSGGWFMTMNLGVHSVMYTYYTMKAAKVKHPNILPMVITSLQILQMVLGTIFGILNYIWRQERGCYTTSEHFFWSFVLYGTYFILFAQFFHRAYLRPKRKAESKSQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473986
EMBL· GenBank· DDBJ
EDL94335.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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