A6JFK0 · A6JFK0_RAT
- ProteinOxygen-regulated protein 1
- GeneRp1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2125 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axoneme | |
Cellular Component | ciliary tip | |
Cellular Component | cilium | |
Cellular Component | microtubule associated complex | |
Cellular Component | photoreceptor cell cilium | |
Cellular Component | photoreceptor connecting cilium | |
Cellular Component | photoreceptor inner segment | |
Cellular Component | photoreceptor outer segment | |
Molecular Function | microtubule binding | |
Biological Process | axoneme assembly | |
Biological Process | cellular response to light stimulus | |
Biological Process | intracellular signal transduction | |
Biological Process | photoreceptor cell development | |
Biological Process | photoreceptor cell maintenance | |
Biological Process | photoreceptor cell outer segment organization | |
Biological Process | positive regulation of non-motile cilium assembly | |
Biological Process | retina development in camera-type eye | |
Biological Process | retina morphogenesis in camera-type eye | |
Biological Process | retinal cone cell development | |
Biological Process | retinal rod cell development | |
Biological Process | visual perception |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameOxygen-regulated protein 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6JFK0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Interacts (via the doublecortin domains) with microtubules. Interacts with RP1L1. Interacts with MAK.
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MSETPSTSFSMIRLTSSEGQVPSRHSN | ||||||
Domain | 35-117 | Doublecortin | ||||
Sequence: KRISFYKSGDPQFGGVRVVVNPRSFKTFDALLDNLSRKVPLPFGVRNISTPRGRHSITKLEELEDGESYVCSHNKKVLPVDLD | ||||||
Domain | 157-236 | Doublecortin | ||||
Sequence: RRLVVFRNGDPKTRRVVLLSRRITQSFEAFLQYLTQVMQYPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYD | ||||||
Region | 638-662 | Disordered | ||||
Sequence: EHPGNGRQISSPFASKKKKKSQQRM | ||||||
Region | 910-991 | Disordered | ||||
Sequence: EHRKSAPLGQDRSNVVNYNSNGFPENNLPTTSSKGKSFLMESNKRKTKNANWKGNKNQETSKSLVVKDNGEQPNKHSCESQD | ||||||
Compositional bias | 919-947 | Polar residues | ||||
Sequence: QDRSNVVNYNSNGFPENNLPTTSSKGKSF | ||||||
Compositional bias | 962-979 | Polar residues | ||||
Sequence: KGNKNQETSKSLVVKDNG | ||||||
Region | 1393-1460 | Disordered | ||||
Sequence: DYSPLEEFQNCPPKKIVNKKKSVSSDKEDSRTSEEPRSITNSVTSSERNATSELESFEESESQDTGIF | ||||||
Compositional bias | 1411-1427 | Basic and acidic residues | ||||
Sequence: KKKSVSSDKEDSRTSEE | ||||||
Compositional bias | 1428-1443 | Polar residues | ||||
Sequence: PRSITNSVTSSERNAT | ||||||
Region | 1554-1577 | Disordered | ||||
Sequence: YTDSSLNCNKQHRSPGTLDWSDYG | ||||||
Region | 1820-1842 | Disordered | ||||
Sequence: NCPKEKIPNHHKEEKRNSPSERT | ||||||
Compositional bias | 1824-1839 | Basic and acidic residues | ||||
Sequence: EKIPNHHKEEKRNSPS |
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,125
- Mass (Da)237,897
- Last updated2023-06-28 v1
- ChecksumD27F226B0EA27B72
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 919-947 | Polar residues | ||||
Sequence: QDRSNVVNYNSNGFPENNLPTTSSKGKSF | ||||||
Compositional bias | 962-979 | Polar residues | ||||
Sequence: KGNKNQETSKSLVVKDNG | ||||||
Compositional bias | 1411-1427 | Basic and acidic residues | ||||
Sequence: KKKSVSSDKEDSRTSEE | ||||||
Compositional bias | 1428-1443 | Polar residues | ||||
Sequence: PRSITNSVTSSERNAT | ||||||
Compositional bias | 1824-1839 | Basic and acidic residues | ||||
Sequence: EKIPNHHKEEKRNSPS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH473984 EMBL· GenBank· DDBJ | EDM11596.1 EMBL· GenBank· DDBJ | Genomic DNA |