A6J991 · A6J991_RAT
- ProteinCytochrome P450
- GeneCyp2s1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids499 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Cytochromes P450 are a group of heme-thiolate monooxygenases.
Catalytic activity
- an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | intracellular membrane-bounded organelle | |
Molecular Function | arachidonic acid epoxygenase activity | |
Molecular Function | heme binding | |
Molecular Function | hydro-lyase activity | |
Molecular Function | iron ion binding | |
Molecular Function | monooxygenase activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
Molecular Function | thromboxane-A synthase activity | |
Biological Process | epoxygenase P450 pathway | |
Biological Process | icosanoid metabolic process | |
Biological Process | prostaglandin metabolic process | |
Biological Process | retinoic acid metabolic process | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome P450
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6J991
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 297-318 | Helical | ||||
Sequence: YLLFAGTMTIGATIRYALLLLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MEAASTWALLLALLLLLLALTLP | ||||||
Chain | PRO_5039952653 | 24-499 | Cytochrome P450 | |||
Sequence: RTPARGQLPPGPTPLPLLGNLLQLRPGALYSGFLRLSKKYGPVFTVHLGPWRRVVVLVGHDAIREALGGQAEEFSGRGTLATLDKTFDGHGVFFANGERWKQLRKFTLLALRDLGMGKREGEELIQEEVQNLVKAFQRTEGRPFNPSMLLAQATSNVVCSLIFGIRLPYEDKEFQAVIQAASGTLLGISSPWGQAYEMFSWLLQPLPGPHTQLQHHLGTLAAFTIQQVQRHQGRSHTSGPARDVVDAFLQKMAQEKEDPGTEFTEKNLLMTVTYLLFAGTMTIGATIRYALLLLLKYPQVQKRVREELIQELGPSRTPSLSDRVRLPYTDAVLHEAQRLLALVPMGMPHTVTKTTSFRGYTLPKGTEVFPLIGSVLHDPAVFRNPEEFHPSRFLDDDGRIRKHEAFLPYSLGKRVCLGEGLARAELWLFFTSILQAFSLDTPCPPGDLSLKPAVRGLFNIPPDFQLQVWPTGDQSR |
Sequence
- Sequence statusComplete
- Length499
- Mass (Da)55,548
- Last updated2023-06-28 v1
- Checksum36C42D352F6B44CE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH473979 EMBL· GenBank· DDBJ | EDM07993.1 EMBL· GenBank· DDBJ | Genomic DNA |