A6IWP7 · A6IWP7_RAT

  • Protein
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Gene
    Naxd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site171(6S)-NADPHX (UniProtKB | ChEBI)
Binding site224-230(6S)-NADPHX (UniProtKB | ChEBI)
Binding site264-268ATP (UniProtKB | ChEBI)
Binding site283-292ATP (UniProtKB | ChEBI)
Binding site293(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular FunctionATP-dependent NAD(P)H-hydrate dehydratase activity
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ATP-dependent NAD(P)HX dehydratase
    • Carbohydrate kinase domain-containing protein

Gene names

    • Name
      Naxd
    • Synonyms
      CARKD
      , RGD1562691_predicted
    • ORF names
      rCG_43121

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6IWP7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane28-53Helical

Keywords

PTM/Processing

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain71-362YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    38,731
  • Last updated
    2023-06-28 v1
  • Checksum
    357007FF5852CF82
MGIRCVAIRACGGGKIDTGVPRMAVCPYGAAAVVMALLSAAIAFHCSPLLAVLQRALSLHTAHATKDMDNLFQLVRNIVPALTSKKHKGQDGRIGIVGGCQEYTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSDAVEEVEKWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLIAQRPALVHGYQKAVLTPNHVEFSRLWDAVLSSPMDTSNHSGSVLKLSQALGNITIVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMAHWALRAGPEKTNGSSPLLVAAWGACTLTRECNHLAFQKYGRSTTTTDMIAEVGAAFSKLFTT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473970
EMBL· GenBank· DDBJ
EDM08823.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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