A6ITH9 · A6ITH9_RAT

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Cellular Componentneuronal cell body
Cellular Componentperoxisome
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionp53 binding
Molecular FunctionSUMO transferase activity
Molecular Functionubiquitin protein ligase activity
Molecular Functionubiquitin protein ligase binding
Molecular Functionubiquitin-protein transferase activity
Biological Processcellular response to exogenous dsRNA
Biological Processmitochondrial fission
Biological Processmitochondrion localization
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of chemokine (C-C motif) ligand 5 production
Biological Processnegative regulation of defense response to virus by host
Biological Processnegative regulation of innate immune response
Biological Processnegative regulation of mitochondrial fusion
Biological Processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processnegative regulation of type I interferon-mediated signaling pathway
Biological Processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
Biological Processpositive regulation of dendrite extension
Biological Processpositive regulation of mitochondrial fission
Biological Processpositive regulation of protein sumoylation
Biological Processprotein destabilization
Biological Processprotein polyubiquitination
Biological Processprotein stabilization
Biological Processprotein ubiquitination
Biological Processregulation of mitochondrial membrane potential
Biological Processregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Biological Processregulation of mitochondrion organization
Biological Processregulation of protein stability

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RING-type E3 ubiquitin transferase
  • EC number

Gene names

    • Name
      Mul1
    • Synonyms
      RGD1309944_predicted
    • ORF names
      rCG_31103

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BN
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6ITH9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane139-159Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain202-240RING-type

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    28,930
  • Last updated
    2023-06-28 v1
  • Checksum
    2E707B7E5080412C
MVWNRTTHLWNDYSKIIHQRTNTVPFDLVPHEDGVAMAVRVLKPLDSVDLGLETVYEKFHPSVQSFTDAIGHYISGERPKGVQETEEMLKVGATLTGIGELVLDNNSVRLQPPKQGMQYYLSSQDFDSLLHRQESSVRLWKVLVLVFGFATCATLFFILRKQYLQRQERLRQQQLQDEFLEHEAHLLSQASPEDRESLKSACVVCLSNFKSCVFLECGHVCSCRQCYLALPEPKRCPICRRGITRVIPLYNS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473968
EMBL· GenBank· DDBJ
EDL80880.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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