A6IIQ9 · A6IIQ9_RAT

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentriole
Cellular Componentciliary basal body
Cellular Componentgamma-tubulin complex
Cellular Componentnuclear speck
Cellular Componentnucleus
Cellular Componentphotoreceptor connecting cilium
Cellular ComponentPML body
Cellular Componentspindle pole
Cellular Componentubiquitin ligase complex
Molecular Functionantigen binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase binding
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Molecular FunctionSUMO transferase activity
Molecular Functionubiquitin protein ligase activity
Molecular Functionubiquitin-protein transferase activity
Biological ProcessDNA damage response
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Processmaintenance of protein location in nucleus
Biological Processpositive regulation of DNA-templated transcription
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein K48-linked ubiquitination
Biological Processprotein localization to nucleus
Biological Processprotein monoubiquitination
Biological Processprotein polyubiquitination
Biological Processprotein sumoylation
Biological Processregulation of cell population proliferation
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RING-type E3 ubiquitin transferase
  • EC number

Gene names

    • Name
      Topors
    • Synonyms
      Topors_predicted
    • ORF names
      rCG_54993

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6IIQ9

Proteomes

Organism-specific databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-41Disordered
Domain104-143RING-type
Region440-476Disordered
Region495-693Disordered
Compositional bias517-535Polar residues
Compositional bias543-569Basic and acidic residues
Compositional bias610-630Basic residues
Compositional bias654-672Polar residues
Region714-950Disordered
Compositional bias730-745Polar residues
Compositional bias746-772Basic and acidic residues
Compositional bias783-809Basic and acidic residues
Compositional bias820-851Basic and acidic residues
Compositional bias878-898Basic residues
Compositional bias922-947Polar residues
Compositional bias975-1036Polar residues
Region975-1042Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,042
  • Mass (Da)
    117,793
  • Last updated
    2023-06-28 v1
  • Checksum
    4CDFCF601719E6CC
MGSQPPPLGSPLSREEGEAPPLAPAEEGRRRSRRVRLRGSCRHRPSLLGRRELASSGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTAPEVRRFRYRTTMTRERNASLYSPSSTVSRRTSTPPDSGVLFEGLGISTRPRDVDIPQFMRHMALRGPTATDERSLRKVQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAEAQELDVNVSTIRQAPWDDETPGPSYSNSEQVHVGVSSLLNSSDSSDEELVSGGAASQIQGVQANDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGSYEKMETVKTQEQEQSYSSGDSDASRASSPRSVLGKDEQMGKSHCDSDTRINSKKEEKRSTSLSTPRDSSSTRGDRACSPYNHRHRKGGRSRSSDSRSQSRSGHDQRNHRKHHGKKRLKNKRSRSRESSSKPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARRKNHSERKYYYYERHRSRSVSSNRSRTTSAVPDRMRNEKPGGKRKYKTRHLEDTNEEAQPSRAFASRVKESHYQKPSKLDGGSKDESDSFSDSRPSDRETKHKRRKRRARSLSVEIVYEGKATDTSKHHKKKKKKHKKKHRKHHGDNTSRSPVVITIDSDSDGDAGVKASVECSQSSLPQPGQDEVSTPSSEAFETKDVVTIEDELAVEDKECDVTALTNDLSTSQAVESSESPPVSVEQTLDVREDSTFASDVESQSSNASIPTEPSRPLPSPRTSLSSVSPGRDCDMS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias517-535Polar residues
Compositional bias543-569Basic and acidic residues
Compositional bias610-630Basic residues
Compositional bias654-672Polar residues
Compositional bias730-745Polar residues
Compositional bias746-772Basic and acidic residues
Compositional bias783-809Basic and acidic residues
Compositional bias820-851Basic and acidic residues
Compositional bias878-898Basic residues
Compositional bias922-947Polar residues
Compositional bias975-1036Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473962
EMBL· GenBank· DDBJ
EDL98629.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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