Knockdown the moyamoya disease susceptibility gene RNF213 upregulates the expression of basic fibroblast growth factor and matrix metalloproteinase-9 in bone marrow derived mesenchymal stem cells.
FGF2 gene's antisense protein NUDT6 plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling.
Connexin43 Region 266-283 via Src Inhibition Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.
MicroRNA-23c expression decreases during chondrogenic differentiation of marrow stromal cells (MSCs) which inhibits MSCs differentiation to chondrocytes by inhibiting FGF2
Results provide further indirect evidence that endogenous hippocampal fibroblast growth factor 2 may mediate individual differences in conditioned fear expression.
Study shows that basic fibroblast growth factor enhances cell proliferation in the dentate gyrus of neonatal rats following hypoxic-ischemic brain damage.
Thus FGF2 is an alcohol-responsive gene constituting a positive regulatory feedback loop with alcohol. This loop leads to facilitation of alcohol consumption marking FGF2 as a potential new therapeutic target for alcohol addiction.
vein-derived bFGF may contribute to the therapeutic efficacy of vein wrapping for recurrent compressive neuropathy through the induction of HO-1 expression
Study shows that fibroblast growth factor 2-ERK1/2 pathway is involved in the pathophysiology of depressive-like behaviors and manipulating the neurogenesis pathway is a viable therapeutic approach to inflammation-associated depression.
overexpression of BNIP3L in H9C2 cardiomyoblast cells reduced the cardioprotection of FGF-2 in hydrogen peroxide-induced necrosis and mitochondrial dysfunction.
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