A6IEW0 · A6IEW0_RAT

  • Protein
    non-specific serine/threonine protein kinase
  • Gene
    Braf
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1785100200300400500600700
TypeIDPosition(s)Description
Binding site501ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell body
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentglutamatergic synapse
Cellular Componentmitochondrion
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynapse
Cellular Componentpresynapse
Molecular FunctionATP binding
Molecular Functioncalcium ion binding
Molecular Functionidentical protein binding
Molecular FunctionMAP kinase kinase activity
Molecular FunctionMAP kinase kinase kinase activity
Molecular Functionmitogen-activated protein kinase kinase binding
Molecular Functionprotein kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein-containing complex binding
Molecular Functionscaffold protein binding
Molecular Functionsmall GTPase binding
Biological Processalpha-beta T cell differentiation
Biological ProcessCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
Biological ProcessCD4-positive, alpha-beta T cell differentiation
Biological Processcell differentiation
Biological Processcellular response to calcium ion
Biological Processcellular response to nerve growth factor stimulus
Biological Processcellular response to xenobiotic stimulus
Biological Processendothelial cell apoptotic process
Biological Processepidermal growth factor receptor signaling pathway
Biological ProcessERK1 and ERK2 cascade
Biological Processestablishment of protein localization to membrane
Biological Processface development
Biological Processhead morphogenesis
Biological Processlong-term synaptic potentiation
Biological ProcessMAPK cascade
Biological Processmyeloid progenitor cell differentiation
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of endothelial cell apoptotic process
Biological Processnegative regulation of fibroblast migration
Biological Processnegative regulation of neuron apoptotic process
Biological Processnegative regulation of synaptic vesicle exocytosis
Biological Processpositive regulation of axon regeneration
Biological Processpositive regulation of axonogenesis
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of glucose transmembrane transport
Biological Processpositive regulation of stress fiber assembly
Biological Processpositive regulation of substrate adhesion-dependent cell spreading
Biological Processpositive T cell selection
Biological Processpostsynaptic modulation of chemical synaptic transmission
Biological Processprotein phosphorylation
Biological Processregulation of axon regeneration
Biological Processregulation of cell population proliferation
Biological Processregulation of T cell differentiation
Biological Processresponse to cAMP
Biological Processresponse to peptide hormone
Biological Processsomatic stem cell population maintenance
Biological Processstress fiber assembly
Biological Processsubstrate adhesion-dependent cell spreading
Biological Processsynaptic vesicle exocytosis
Biological ProcessT cell differentiation in thymus
Biological ProcessT cell receptor signaling pathway
Biological Processthymus development
Biological Processthyroid gland development
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    non-specific serine/threonine protein kinase
  • EC number

Gene names

    • Name
      Braf
    • ORF names
      rCG_28080

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6IEW0

Proteomes

Organism-specific databases

PTM/Processing

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-54Disordered
Domain171-243RBD
Domain250-296Phorbol-ester/DAG-type
Region322-474Disordered
Compositional bias323-352Polar residues
Compositional bias407-453Polar residues
Compositional bias454-469Basic and acidic residues
Domain475-735Protein kinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    785
  • Mass (Da)
    85,838
  • Last updated
    2023-06-28 v1
  • Checksum
    4E3FA3DC00774131
MAALSGGGGSSSGGGGGGGGGGGGGGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGADFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQTPTDVSRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEAFSAETTLPSGCSSAPPSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSTEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias323-352Polar residues
Compositional bias407-453Polar residues
Compositional bias454-469Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473959
EMBL· GenBank· DDBJ
EDM15397.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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