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A6IDJ7 · A6IDJ7_RAT

  • Protein
    Protein maelstrom homolog
  • Gene
    Mael
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautosome
Cellular Componentchromatin
Cellular Componentchromatoid body
Cellular Componentcytoplasm
Cellular Componentmale germ cell nucleus
Cellular Componentnucleus
Cellular ComponentP granule
Cellular Componentperinuclear region of cytoplasm
Cellular ComponentpiP-body
Cellular ComponentXY body
Molecular Functionsequence-specific DNA binding
Biological Processapoptotic process
Biological Processcell morphogenesis
Biological ProcessDNA damage response
Biological Processectopic germ cell programmed cell death
Biological Processfertilization
Biological Processgene expression
Biological Processhomologous chromosome pairing at meiosis
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processmale meiotic nuclear division
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of developmental process
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of reproductive process
Biological Processnegative regulation of transcription by RNA polymerase II
Biological ProcesspiRNA processing
Biological Processregulation of miRNA-mediated gene silencing
Biological Processregulation of organ growth
Biological Processregulatory ncRNA-mediated gene silencing
Biological ProcesssiRNA-mediated retrotransposon silencing by heterochromatin formation
Biological Processspermatogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein maelstrom homolog

Gene names

    • Name
      Mael
    • Synonyms
      Mael_predicted
    • ORF names
      rCG_46061

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6IDJ7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain2-71HMG box
Region60-79Disordered
Domain130-326Maelstrom

Sequence similarities

Belongs to the maelstrom family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    49,300
  • Last updated
    2023-06-28 v1
  • MD5 Checksum
    07F936B0D069B8D435C5581C57E705EE
MPNRRASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSADWALLREDEKEKYSEMAREWRAAQGKDSGPSEKQKLVSTPLRRPGMLVPKPSVSPPDMSNLSIKSDQALLGGVFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNFEFGHDQATVLQNLYKFIHPNPGNWPPIYCKSDDRARVNWCLKRMERASEIRQDLELLTVEDLVVGIYQQKFLKEPSKTWVRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTGAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVESPGFCHFNSYNQEQRSNSSTGYYPSGVKISGSNSSVRGRGITRLLESISNSSNNIHRFSNCEASLSPYMPQKDGYKPFSSFS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473958
EMBL· GenBank· DDBJ
EDM09300.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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