A6I5P9 · A6I5P9_RAT

  • Protein
    Phospholipid phosphatase 1
  • Gene
    Plpp1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

  • (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-ethanolamine phosphate + H2O = N-(9Z-octadecenoyl) ethanolamine + phosphate
    This reaction proceeds in the forward direction.
  • N-(octanoyl)-sphing-4-enine-1-phosphate + H2O = N-octanoylsphing-4-enine + phosphate
    This reaction proceeds in the forward direction.
  • a monoacyl-sn-glycero-3-phosphate + H2O = a monoacylglycerol + phosphate
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.4 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.75 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.106 (UniProtKB | ENZYME | Rhea)
  • an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism; phospholipid metabolism.
Phospholipid metabolism.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcaveola
Molecular Functionphosphatidate phosphatase activity
Biological Processphospholipid dephosphorylation
Biological Processphospholipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipid phosphatase 1
  • EC number
  • Alternative names
    • Lipid phosphate phosphohydrolase 1
    • PAP2-alpha
    • Phosphatidate phosphohydrolase type 2a
    • Phosphatidic acid phosphatase 2a

Gene names

    • Name
      Plpp1
    • Synonyms
      Ppap2a
    • ORF names
      rCG_44744

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6I5P9

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Membrane raft
; Multi-pass membrane protein
Membrane, caveola
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane59-82Helical
Transmembrane94-112Helical
Transmembrane166-186Helical
Transmembrane198-217Helical
Transmembrane229-251Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity. Can also form heterooligomers with PLPP2 and PLPP3.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain103-244Phosphatidic acid phosphatase type 2/haloperoxidase
Region258-283Disordered

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    283
  • Mass (Da)
    31,912
  • Last updated
    2023-06-28 v1
  • Checksum
    DD7F47EBAD51C9B2
MFDKTRLPYVVLDVICVLLASMPMAVVNLGQIYPFQRGFFCSDNSVKYPYHDSTVTTSVLVLVGLGIPIFSMITGETLSVYFNVLHSNSFVSNHYIATIYKAVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCSDGYIENFVCQGNEQKVREGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYVTDFFKTTESNKERKEDSHTTLHETSNRQSYARNHEP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473955
EMBL· GenBank· DDBJ
EDM10358.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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