A6I4Z8 · A6I4Z8_RAT

  • Protein
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
  • Gene
    Ndufs6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Cellular Componentrespiratory chain complex I
Biological Processcellular senescence
Biological Processcirculatory system development
Biological ProcessDNA damage response, signal transduction by p53 class mediator
Biological Processfatty acid metabolic process
Biological Processgene expression
Biological Processkidney development
Biological Processmesenchymal stem cell differentiation
Biological Processmesenchymal stem cell proliferation
Biological Processmitochondrial electron transport, NADH to ubiquinone
Biological Processmitochondrial respiratory chain complex I assembly
Biological Processmitochondrion organization
Biological Processmulticellular organism growth
Biological Processmuscle contraction
Biological Processreactive oxygen species metabolic process
Biological Processregulation of membrane potential
Biological Processregulation of mitochondrial membrane potential
Biological Processreproductive system development
Biological Processrespiratory electron transport chain
Biological Processstem cell division

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene names

    • Name
      Ndufs6
    • ORF names
      rCG_44483

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6I4Z8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain75-111Zinc finger CHCC-type

Sequence similarities

Belongs to the complex I NDUFS6 subunit family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    116
  • Mass (Da)
    12,797
  • Last updated
    2023-06-28 v1
  • Checksum
    32BD96137877F25C
MVAALTFRRLLALPRAARGFGVRVSLSGEKITHTGQVSDGKDYRGIRFVDRQKEVNENFAIDLIAQQPVNEVDRRIIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFKQQHH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473955
EMBL· GenBank· DDBJ
EDM10106.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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