A6I4V3 · A6I4V3_RAT
- ProteinBetaine--homocysteine S-methyltransferase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids407 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
Catalytic activity
- L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionineThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 217 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 299 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 300 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | S-methyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | methionine biosynthetic process | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBetaine--homocysteine S-methyltransferase 1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6I4V3
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length407
- Mass (Da)44,993
- Last updated2023-06-28 v1
- Checksum983F71645A69547F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH473955 EMBL· GenBank· DDBJ | EDM10062.1 EMBL· GenBank· DDBJ | Genomic DNA |