A6HNQ5 · A6HNQ5_RAT

  • Protein
    Methylthioribulose-1-phosphate dehydratase
  • Gene
    Apip
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site96substrate
Binding site114Zn2+ (UniProtKB | ChEBI)
Binding site116Zn2+ (UniProtKB | ChEBI)
Active site138Proton donor/acceptor
Binding site194Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentmembrane
Molecular Functionidentical protein binding
Molecular Functionmethylthioribulose 1-phosphate dehydratase activity
Molecular Functionzinc ion binding
Biological Processapoptotic process
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine
Biological Processnegative regulation of apoptotic process
Biological Processprotein homotetramerization
Biological Processpyroptotic inflammatory response
Biological Processregulation of ERK1 and ERK2 cascade

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylthioribulose-1-phosphate dehydratase
  • EC number
  • Short names
    MTRu-1-P dehydratase
  • Alternative names
    • APAF1-interacting protein

Gene names

    • Name
      Apip
    • Synonyms
      APIP
      , Apip_predicted
    • ORF names
      rCG_27338

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6HNQ5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Endomembrane system
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer. Interacts with APAF1. May interact with CASP1.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-221Class II aldolase/adducin N-terminal

Sequence similarities

Belongs to the aldolase class II family. Adducin subfamily.
Belongs to the aldolase class II family. MtnB subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    27,053
  • Last updated
    2023-06-28 v1
  • MD5 Checksum
    9019C8F6E4C4D80F7CC1DC16C9AD28D3
MSGCQAQGDCCSRPYGAQDKEHPRFLIPELCKQFYHLGWVTGTGGGISLKHGNEIYIAPSGVQKERIQPEDMFVCDINEQDISGPPASKNLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGQEFKITHQEMIKGIRKCTSGGYYRYDDILVVPIIENTPEEKDLKERMARAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKMGLDPTQFPVGEHGIV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473949
EMBL· GenBank· DDBJ
EDL79656.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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