A6HMC4 · A6HMC4_RAT
- ProteinEndoplasmic reticulum junction formation protein lunapark
- GeneLnp_predicted
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Plays a role in determining ER morphology.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum tubular network membrane | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Biological Process | endoplasmic reticulum tubular network maintenance | |
Biological Process | positive regulation of endoplasmic reticulum tubular network organization |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEndoplasmic reticulum junction formation protein lunapark
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6HMC4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Interaction
Subunit
Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Basic and acidic residues | ||||
Sequence: MEKETYKTAKLILERFDPDSKKAKEF | ||||||
Region | 1-121 | Disordered | ||||
Sequence: MEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAATAKPGQEIRQRTAAQRNLSPAPANSNQGPPPQVPVSPGPSKDASAPGGPPERTVAPALPRRLGSPATSVPGMGLHPPGPPLARPVL | ||||||
Compositional bias | 43-58 | Polar residues | ||||
Sequence: IRQRTAAQRNLSPAPA | ||||||
Domain | 128-177 | Lunapark | ||||
Sequence: LDRIVEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYIAFRCAYCFFLN | ||||||
Region | 184-302 | Disordered | ||||
Sequence: PQAPRLPEFSFEKRQAVEGSSSTGPMLLESVPSPENQLTEDSLEEQDDLDNSTEQKDDKIPVTEQTNQVIEETSGPEGSEENQEETENEETSTNEAKSPVLRSDSVSNLELSEDSVVTK | ||||||
Compositional bias | 198-222 | Polar residues | ||||
Sequence: QAVEGSSSTGPMLLESVPSPENQLT | ||||||
Compositional bias | 245-259 | Polar residues | ||||
Sequence: VTEQTNQVIEETSGP | ||||||
Compositional bias | 276-302 | Polar residues | ||||
Sequence: TNEAKSPVLRSDSVSNLELSEDSVVTK |
Domain
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence similarities
Belongs to the lunapark family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)32,862
- Last updated2023-06-28 v1
- ChecksumF700CBB02047B8BC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Basic and acidic residues | ||||
Sequence: MEKETYKTAKLILERFDPDSKKAKEF | ||||||
Compositional bias | 43-58 | Polar residues | ||||
Sequence: IRQRTAAQRNLSPAPA | ||||||
Compositional bias | 198-222 | Polar residues | ||||
Sequence: QAVEGSSSTGPMLLESVPSPENQLT | ||||||
Compositional bias | 245-259 | Polar residues | ||||
Sequence: VTEQTNQVIEETSGP | ||||||
Compositional bias | 276-302 | Polar residues | ||||
Sequence: TNEAKSPVLRSDSVSNLELSEDSVVTK |