A6HGP2 · A6HGP2_RAT

Function

function

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
Plays a role in nonsense-mediated mRNA decay.

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentexon-exon junction complex
Cellular Componentnucleolus
Cellular Componentnucleus
Cellular Componenttelomerase holoenzyme complex
Molecular FunctionDNA polymerase binding
Molecular Functionmanganese ion binding
Molecular Functionribonucleoprotein complex binding
Molecular FunctionRNA binding
Molecular FunctionRNA endonuclease activity
Molecular Functiontelomerase RNA binding
Molecular Functiontelomeric DNA binding
Biological Processnegative regulation of telomere capping
Biological Processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Processregulation of telomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Telomerase-binding protein EST1A
  • EC number

Gene names

    • Name
      Smg6
    • Synonyms
      LOC287522
    • ORF names
      rCG_34587

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A6HGP2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-27Disordered
Region83-104Disordered
Compositional bias84-104Basic and acidic residues
Region229-455Disordered
Compositional bias231-284Basic and acidic residues
Compositional bias309-325Polar residues
Compositional bias328-398Basic and acidic residues
Region470-543Disordered
Compositional bias516-530Polar residues
Region910-936Disordered
Domain1299-1450PIN

Domain

The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,472
  • Mass (Da)
    165,751
  • Last updated
    2023-06-28 v1
  • Checksum
    2E7C391FACB2AE11
MLLLPVRPPSFGEGRQEGAGKRVGVGERAPPVRRGFLAARGGGGVAAAVAAAAKMAEGLERVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKTKEASGNEEFKDEIVNDRDASAVGNDTQLIKVCKELDSQQQNGPIDAENSQAQETFSKTVGLEDRSLKIIKRIKKPDLQIYQPGRRLQTVTKESAGRADEEEILNQVEQLTMEGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTDDSVQGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKENRGALRVTFDAEAMSKDSPVVRSVKENVDRMNSDKGSSSGGKGSEKQEFRNPKQELRDRGRGILILPAHTALSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGDSRQAQASFYKFQNSDNPYYYPRTPGPASQYPYTGYSPLQYPVGPTNGMYPGPYYPGYPAPSGQYVCSPLPASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNIENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHSRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAASLGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGIQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias84-104Basic and acidic residues
Compositional bias231-284Basic and acidic residues
Compositional bias309-325Polar residues
Compositional bias328-398Basic and acidic residues
Compositional bias516-530Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473948
EMBL· GenBank· DDBJ
EDM05197.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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