A6HGP2 · A6HGP2_RAT
- ProteinTelomerase-binding protein EST1A
- GeneSmg6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1472 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
Plays a role in nonsense-mediated mRNA decay.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | exon-exon junction complex | |
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Cellular Component | telomerase holoenzyme complex | |
Molecular Function | DNA polymerase binding | |
Molecular Function | manganese ion binding | |
Molecular Function | ribonucleoprotein complex binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA endonuclease activity | |
Molecular Function | telomerase RNA binding | |
Molecular Function | telomeric DNA binding | |
Biological Process | negative regulation of telomere capping | |
Biological Process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
Biological Process | regulation of telomere maintenance |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTelomerase-binding protein EST1A
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA6HGP2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MLLLPVRPPSFGEGRQEGAGKRVGVGE | ||||||
Region | 83-104 | Disordered | ||||
Sequence: RENMKELKEPRQRKDNRRPDLE | ||||||
Compositional bias | 84-104 | Basic and acidic residues | ||||
Sequence: ENMKELKEPRQRKDNRRPDLE | ||||||
Region | 229-455 | Disordered | ||||
Sequence: TMEGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTDDSVQGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKENRGALRVTFDAEAMSKDSPVVRSVKENVDRMNSDKGSSSGGKGSEKQEFRNPKQELR | ||||||
Compositional bias | 231-284 | Basic and acidic residues | ||||
Sequence: EGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTD | ||||||
Compositional bias | 309-325 | Polar residues | ||||
Sequence: TCSTSSAGSNNSAEGAG | ||||||
Compositional bias | 328-398 | Basic and acidic residues | ||||
Sequence: DNGCRRRRQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKE | ||||||
Region | 470-543 | Disordered | ||||
Sequence: LSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGD | ||||||
Compositional bias | 516-530 | Polar residues | ||||
Sequence: QKPALKSQTPQLHFL | ||||||
Region | 910-936 | Disordered | ||||
Sequence: IHPSHSRSSQGTESGKDSEQENGLGSL | ||||||
Domain | 1299-1450 | PIN | ||||
Sequence: LFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRV |
Domain
The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,472
- Mass (Da)165,751
- Last updated2023-06-28 v1
- Checksum2E7C391FACB2AE11
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 84-104 | Basic and acidic residues | ||||
Sequence: ENMKELKEPRQRKDNRRPDLE | ||||||
Compositional bias | 231-284 | Basic and acidic residues | ||||
Sequence: EGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTD | ||||||
Compositional bias | 309-325 | Polar residues | ||||
Sequence: TCSTSSAGSNNSAEGAG | ||||||
Compositional bias | 328-398 | Basic and acidic residues | ||||
Sequence: DNGCRRRRQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKE | ||||||
Compositional bias | 516-530 | Polar residues | ||||
Sequence: QKPALKSQTPQLHFL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH473948 EMBL· GenBank· DDBJ | EDM05197.1 EMBL· GenBank· DDBJ | Genomic DNA |