A6BM01 · A6BM01_BALAC

Function

function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

150350100150200250300350400450500
TypeIDPosition(s)Description
Binding site442Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Molecular Functiontestosterone 6-beta-hydroxylase activity
Biological Processoxidative demethylation
Biological Processsteroid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome P450 3A
  • EC number

Gene names

    • Name
      CYP3A72

Organism names

Accessions

  • Primary accession
    A6BM01

Subcellular Location

Endoplasmic reticulum membrane
; Peripheral membrane protein
Microsome membrane
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane213-233Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    57,316
  • Last updated
    2007-07-24 v1
  • Checksum
    9671F8F84169E15E
MDLIPSFSVETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYFGNILSYRKGLWEFDNRCFKKYGKMWGCYEGQQPLLVITDPDIIKTVLVKECYSVFTNRRAFGPVGIMKNAISLSEDEQWKRIRTLLSPAFTSGKLKEMFPIISQIGDVLVRNLKKEAEKGKPISMKDFFGAYSMDVITGIAFGVNIDSLNNPQDPFVEYSKKILKFNLLSPLLLSIVLFPFLTPVFEALNITLFPKSSLNFLTKSVKRIKESRLKDKQTHRVDFLQLMINSQNSKETDTHKVLSDTELMAQSIIFIFAGYETTSNSLSFIIYELATHPDVQQKLQEEIDATFPNKAPPTYEALVQMEYLDMVLNETLRIFPIAGRLERVCKKDVEVNGVFIPKGTTVVVPLFVLHNDPELWPEPQEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFVIMNMKLALVRILQNFSFKPCKETQIPLKLLTQGLTQVEKPVVLKVVSRDATISGA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB290009
EMBL· GenBank· DDBJ
BAF64509.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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