A5WVS7 · A5WVS7_DANRE
- ProteinInhibitor of growth protein
- Geneing5a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids242 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of an histone acetyltransferase complex.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 191 | Histone H3K4me3 binding | ||||
Sequence: Y | ||||||
Binding site | 192 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 194 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Site | 202 | Histone H3K4me3 binding | ||||
Sequence: M | ||||||
Binding site | 205 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Site | 206 | Histone H3K4me3 binding | ||||
Sequence: D | ||||||
Binding site | 210 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Site | 214 | Histone H3K4me3 binding | ||||
Sequence: W | ||||||
Binding site | 216 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 219 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 232 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 235 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | metal ion binding | |
Molecular Function | methylated histone binding | |
Biological Process | chromatin organization | |
Biological Process | positive regulation of apoptotic signaling pathway | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInhibitor of growth protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA5WVS7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 90-117 | |||||
Sequence: YEMVDKHIRRLDADLARFENELKEKLDV | ||||||
Compositional bias | 118-132 | Basic and acidic residues | ||||
Sequence: SGYESPDNRTHKKVT | ||||||
Region | 118-180 | Disordered | ||||
Sequence: SGYESPDNRTHKKVTGRGNLKEKRRPKGRGRKSSDDESPRKKKMKNSPEFPESILPVHPSDVL | ||||||
Compositional bias | 146-165 | Basic and acidic residues | ||||
Sequence: RGRKSSDDESPRKKKMKNSP | ||||||
Domain | 189-238 | PHD-type | ||||
Sequence: PTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRCTQD |
Domain
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence similarities
Belongs to the ING family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length242
- Mass (Da)28,281
- Last updated2007-07-10 v1
- ChecksumA8CD5E2B5A1610D9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 118-132 | Basic and acidic residues | ||||
Sequence: SGYESPDNRTHKKVT | ||||||
Compositional bias | 146-165 | Basic and acidic residues | ||||
Sequence: RGRKSSDDESPRKKKMKNSP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CABZ01006771 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01006772 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01006773 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01006774 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01078511 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01078514 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CT027565 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FO704722 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
LO017843 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
LO018478 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC162372 EMBL· GenBank· DDBJ | AAI62372.1 EMBL· GenBank· DDBJ | mRNA | ||
BC162642 EMBL· GenBank· DDBJ | AAI62642.1 EMBL· GenBank· DDBJ | mRNA |