A5WDM3 · A5WDM3_PSYWF

Function

function

Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site29Mn2+ 1 (UniProtKB | ChEBI)
Binding site31Mn2+ 1 (UniProtKB | ChEBI)
Binding site64Mn2+ 2 (UniProtKB | ChEBI)
Binding site64Mn2+ 1 (UniProtKB | ChEBI)
Binding site111Mn2+ 2 (UniProtKB | ChEBI)
Binding site111-112substrate
Binding site146Mn2+ 2 (UniProtKB | ChEBI)
Binding site154substrate
Binding site192substrate
Binding site196substrate
Binding site199substrate
Binding site225Mn2+ 2 (UniProtKB | ChEBI)
Binding site225substrate
Binding site227Mn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextrinsic component of plasma membrane
Molecular Functionmanganese ion binding
Molecular FunctionUDP-2,3-diacylglucosamine hydrolase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-2,3-diacylglucosamine hydrolase
  • EC number
  • Alternative names
    • UDP-2,3-diacylglucosamine diphosphatase

Gene names

    • Name
      lpxH
    • Ordered locus names
      PsycPRwf_0812

Organism names

Accessions

  • Primary accession
    A5WDM3

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-229Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the LpxH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    296
  • Mass (Da)
    33,948
  • Last updated
    2007-07-10 v1
  • Checksum
    0253A9D647543D7E
MSNQDFAISSYHHLITTRPYDINRVVISDLHLSADEPALVQAFLALLDDVLVLPNVHQLYILGDWFDAWIGDDAYLSLSATEQKRHWLTPLITKLTELKNKGCQSFVMHGNRDFLIGQDFCDSFGGQLIDEPYLLKLGKMTYRLEHGDALCTDDKRYQRFRKVMRNPLVQWLLLKQPLHKRQALAQKIRSQSALDKSAKSLQIMDVNEQAVTCALKKVDGLIHGHTHRPACHQTHLALNAKARSQTLEFKKRYVLGDWRILDPDTRCEQVQAVIGLALDTQISSSFELVTFEWPTR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000713
EMBL· GenBank· DDBJ
ABQ93764.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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