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A5WDL1 · A5WDL1_PSYWF

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

167850100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site324Acyl-ester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionglycosyltransferase activity
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan L,D-transpeptidase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase MrdA
  • EC number
  • Alternative names
    • Penicillin-binding protein 2
      (PBP-2
      )

Gene names

    • Name
      mrdA
    • Ordered locus names
      PsycPRwf_0800

Organism names

Accessions

  • Primary accession
    A5WDL1

Subcellular Location

Cell inner membrane
; Single-pass membrane protein
Cell membrane
Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-40Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain63-232Penicillin-binding protein dimerisation
Domain265-600Penicillin-binding protein transpeptidase
Region633-678Disordered
Compositional bias648-662Polar residues

Sequence similarities

Belongs to the transpeptidase family. MrdA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    678
  • Mass (Da)
    75,628
  • Last updated
    2007-07-10 v1
  • MD5 Checksum
    49775F5C9E694555C10D9F38B832B9EB
MKQPISSDIRQENRVFISRIFFAALFIFLGLSVLMARYWYLQVYSHEKYITQADNNRVKLISDPPSRGYIYDRNGYLLADNKPVFTAMLSPDEIEDPARTLHLLAPIFDLTEEDITDILARIDKNKNDPVTVKIDITDAQMAQFSERKPFFKGVSIQSKLTRSYPYDDLFAHVIGYVGRINDKESKKIDKERYAGTDLIGKIGIENYYEDLLLGKPGHQAVETNVHGDVLRKLDSTPPVPGNDIYLSLDYGLQKVAQEQLNGRRGAIVAIDPKNGDVLAFVSNPSFDPNPFISGISFKDYGALRDDPDQPLYNRALQGMYPPASTIKPFEGLGAIHYGVMGWNDTIYDPGYFTLPGDSHRFRDWKKGGHGTVNLTKSIVMSVDTYYYKLSYQLGIQRLHDWMIRFGFGSPTGIDLPGEKSGVMPSPKWKKDTYDKDWLPGETISVSIGQGYFLATPLQVANATAMTANLGKKLTPHMLKRSEGAAEVHPIDRPTGQIEFNGTQADWLKMRDAMEETVKRGTGHGIYTPRYRIAGKTGTAQVKSIAQGKSYNKAALDKRHWDHAWFTGFAPVEDPEIAVAVLVENGGGGGSTAAPIGRALFDYWILRRKSDPIVPPTPDELAIIKAQKAEEKARLDAERDAQAALEEALKEQQKQSGTTQPGDKPVEKSADKPKPAQSN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias648-662Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000713
EMBL· GenBank· DDBJ
ABQ93752.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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