A5WCF9 · A5WCF9_PSYWF

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1A
  • EC number

Gene names

    • Ordered locus names
      PsycPRwf_0395

Organism names

Accessions

  • Primary accession
    A5WCF9

Subcellular Location

Cell inner membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-43Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain70-243Glycosyl transferase family 51
Domain336-427Penicillin-binding protein OB-like
Domain429-600Penicillin-binding protein transpeptidase
Region655-685Disordered
Domain721-804Penicillin-binding protein transpeptidase
Compositional bias836-862Polar residues
Region836-940Disordered
Compositional bias890-911Polar residues

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    940
  • Mass (Da)
    103,357
  • Last updated
    2007-07-10 v1
  • Checksum
    10F792BBDF648653
MPQSSANSRLIHYIVSILLAIVALALILVLAFPIGFYGMAMYITPNLPSISEMKSTNLEMPLQIYSKDDKLIGQYGNRMSLPVTYDDIPKNFINAFLAAEDSSFYEHSGISIKGLGRAITEIITEDGGQTGGSTITMQVAKNYFLSPERTFSRKLTELYLARSIEDQLSKEEILTLYVNKIYMGEGAYGIRAAAKKYYSKSLDKLTIAEMATLAGLPKAPSQNNPVSNPEEALERRNWILGRMLELGYITQAQHDTAVKEPIGVHLYKEQLDVNMPYLAEMTRRTLVDRYGEEVVNAGWRVKLTVDSEDQKAADTAIKKGLIGYDRRHGWRGVEAHGEPLSKFTTYSNMVPAKVVEVSGRSFKAELADGEVVTVPWSGMSWAKEYLDANRIRRYPNNASDLVKKDDIVRLIANENKTAWRLTQIPKVQGSLVALDPKTGAVDALVGGFDFRYSKFNRATQGWRQPGSTIKPLNYAAALEKGYRPDSMISDGPLRIGDWQPKNSDNRFYGDMTIRRGLILSRNLVSIRLLQAVGTSDARQLLDQFGLDKDKLPTTLSLALGAGQATPLQMATAYSAFANGGHRIQPYFIDQIYDYDNKLLYLANPQRACALCFNNDLQKLNAKLKQDYEKQAEADAKLHQLALKALAEDPKLLQVADSTQSETVDSADDGAEDEADNAKAKPKNSKASLQAAIEAIRYDAGPQSDRLKPVPITYQVADQAPRILKPNVAYEMAGMLRDVIQRGTGTRAKALGRTDVGGKTGTTNEMKDAWFAGFHPTQVSIVWVGFDQPSTLGRGEYGGVAALPIWVDYMRTALKSVPYQWVSVNNKAKSETAKQEVINLSDDNDNTTAGATGSGSDARITNQKVTDGVVRPPRASLIERQPPKPVEPPKPVNSNNNSNSNSSTNADTSSTRAAPKPAPKPAEKPKAEPKPTENKAAPAND

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias836-862Polar residues
Compositional bias890-911Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000713
EMBL· GenBank· DDBJ
ABQ93350.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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