A5VSF8 · PUR9_BRUO2

Function

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionIMP cyclohydrolase activity
Molecular Functionphosphoribosylaminoimidazolecarboxamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional purine biosynthesis protein PurH

Including 2 domains:

  • Recommended name
    Phosphoribosylaminoimidazolecarboxamide formyltransferase
  • EC number
  • Alternative names
    • AICAR transformylase
  • Recommended name
    IMP cyclohydrolase
  • EC number
  • Alternative names
    • ATIC
    • IMP synthase
    • Inosinicase

Gene names

    • Name
      purH
    • Ordered locus names
      BOV_1749

Organism names

Accessions

  • Primary accession
    A5VSF8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000188501-538Bifunctional purine biosynthesis protein PurH

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-158MGS-like

Domain

The IMP cyclohydrolase activity resides in the N-terminal region.

Sequence similarities

Belongs to the PurH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    538
  • Mass (Da)
    56,463
  • Last updated
    2007-07-10 v1
  • Checksum
    422B27C000CB1EF2
MAVSSKHIPAPDLHRVRRALLSVSDKTGLIDFAKALHANGVEILSTGGTAKSIAAAGIPVKDVSEITGFPEIMDGRVKTLHPAVHGGLLAVRNDPEHVAAIEEHGIGGIDLAVINLYPFEEVRFKGGDYDTTVENIDIGGPAMIRASAKNHAYVATVVDPADYADVVAELEKHSGSLPLAFRKKLAAKAFSRTAAYDAAISNWFAEAIDEETPTYRAVAGKLHSVMRYGENPHQTAGFYLTGEKRPGVATATQLQGKQLSYNNINDTDAAFELVAEFDPARTAAVAIIKHANPCGVAEASTIKEAYLKALACDPVSAFGGIVALNRTLDEEAAEEIVKTFTEVIIAPDATEGAQAIVAAKKNLRLLVTGGLPDPRAKGIAAKTVAGGLLVQSRDNGVVDDLDLKVVTKRAPTEAELNDLKFAFRVGKHVKSNAIVYVKDGATVGIGAGQMSRVDSARIAARKAEDAAEAAGLAAPLTKGCVVASDAFFPFADGLLSAVEAGATAVIQPGGSMRDDEVIAAADEHGIAMVMTGMRHFRH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000708
EMBL· GenBank· DDBJ
ABQ60597.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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