A5UVV6 · GMHA_ROSS1

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site56-58substrate
Binding site65Zn2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site69Zn2+ (UniProtKB | ChEBI)
Binding site98-99substrate
Binding site124-126substrate
Binding site129substrate
Binding site176substrate
Binding site176Zn2+ (UniProtKB | ChEBI)
Binding site184Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA
    • Ordered locus names
      RoseRS_2381

Organism names

Accessions

  • Primary accession
    A5UVV6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000751021-197Phosphoheptose isomerase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain41-197SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    21,168
  • Last updated
    2007-07-10 v1
  • Checksum
    CC5B6F0D97801208
MNSPSDSFTRWVIDEIEASIDVKRRTIETQAPMIVAIAERVVETFRRGGKLLLCGNGGSAADAQHIAAEFVSRFRRERHGLPAIALTTDTSILTAISNDYGYERVFARQVEALGRPGDMVIGISTSGISASVIAAMRAARNGGMATVGFTGASGGTLVDHVDLCLCVPSHNTARIQEVHITVAHVVCEIVERTLFEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000686
EMBL· GenBank· DDBJ
ABQ90759.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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