A5UK92 · PYRH_METS3
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- ATP + UMP = ADP + UDP
Activity regulation
Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-10 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GS | ||||||
Binding site | 43 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 44 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 48 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 65 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 113-119 | UMP (UniProtKB | ChEBI) | ||||
Sequence: TEPAHST | ||||||
Binding site | 139 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 145 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 148 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter
Accessions
- Primary accessionA5UK92
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000053957 | 1-225 | Uridylate kinase | |||
Sequence: MKIVVAIGGSILLKEYDCKKFQEYSEILKSLASEHEIFVVVGGGKPAREYIGVVRELGAGEAQCDDIGIEVTRINAKLLLSALGDAAYQKVPHNFQEALEYSATGKIIVMGGTEPAHSTDAVSAILAEYIHADKLINLTSVDGMYDKDPNKYEDAKLIKEITASEMIEFISGKDTKAGTYEFFDMTAIQMIKRSSLETVIANGYDSENLIKAINGEEVGTKVISK |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)24,507
- Last updated2007-07-10 v1
- ChecksumE925AAD6C7CEFF35
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000678 EMBL· GenBank· DDBJ | ABQ86620.1 EMBL· GenBank· DDBJ | Genomic DNA |