A5UG09 · AROK_HAEIG
- ProteinShikimate kinase
- GenearoK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids180 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity
- ATP + shikimate = 3-phosphoshikimate + ADP + H+
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-19 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GAGKST | ||||||
Binding site | 18 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 36 | substrate | ||||
Sequence: D | ||||||
Binding site | 60 | substrate | ||||
Sequence: R | ||||||
Binding site | 82 | substrate | ||||
Sequence: G | ||||||
Binding site | 120 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 140 | substrate | ||||
Sequence: R | ||||||
Binding site | 157 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate kinase
- EC number
- Short namesSK
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionA5UG09
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000022976 | 1-180 | Shikimate kinase | |||
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMDFIDSDAVIEERTGADISWIFDLEGEDGFRKREERIINELTQMQGIVLSTGGGAVLSKENRNYLSARGIVIYLETTVEKQFQRTQRDKKRPLLQDAENPRQVLEDLAKIRNPLYEEIADITLPTDEQNAKIMVNQIVDLIDNMNGLNGAL |
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length180
- Mass (Da)20,292
- Last updated2007-07-10 v1
- ChecksumE430C65F542B0C84
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000672 EMBL· GenBank· DDBJ | ABQ99714.1 EMBL· GenBank· DDBJ | Genomic DNA |