A5UDR7 · DXR_HAEIE

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12NADPH (UniProtKB | ChEBI)
Binding site13NADPH (UniProtKB | ChEBI)
Binding site14NADPH (UniProtKB | ChEBI)
Binding site15NADPH (UniProtKB | ChEBI)
Binding site38NADPH (UniProtKB | ChEBI)
Binding site39NADPH (UniProtKB | ChEBI)
Binding site40NADPH (UniProtKB | ChEBI)
Binding site126NADPH (UniProtKB | ChEBI)
Binding site1271-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site128NADPH (UniProtKB | ChEBI)
Binding site152Mn2+ (UniProtKB | ChEBI)
Binding site1531-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1541-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site154Mn2+ (UniProtKB | ChEBI)
Binding site1881-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2111-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site217NADPH (UniProtKB | ChEBI)
Binding site2241-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2291-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2301-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2331-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site233Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionmetal ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      dxr
    • Ordered locus names
      CGSHiEE_08025

Organism names

Accessions

  • Primary accession
    A5UDR7

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000202671-3971-deoxy-D-xylulose 5-phosphate reductoisomerase

Structure

Family & Domains

Sequence similarities

Belongs to the DXR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    397
  • Mass (Da)
    43,712
  • Last updated
    2007-07-10 v1
  • Checksum
    FD1198F20F53FE57
MQKQNIVILGSTGSIGKSTLSVIENNPEKYHAFALVGGKNVETMFEQCIKFRPHFAALDDVNAAKILREKLIAHHIPTEVLAGQRAICELAAHPDADQIMASIVGAAGLLPTLSAVKAGKRVLLANKESLVTCGQLFIDAVKNYSAKLLPVDSEHNAIFQSLPPEAQEKIGFCPLSELGVSKIILTGSGGPFRYTPLEQFTNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFNASAEEMEVIIHPQSIIHSMVRYVDGSVIAQMGNPDMRTPIAETMAYPHRTFAGVEPLDFFKIKELTFIEPDFNRYPNLKLAIDAFAAGQYATTAMNTANEIAVQAFLDRQISFMDIAKINLKTIEKISPYTIQNIDDVLEIDAQAREIAKTLIRE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000671
EMBL· GenBank· DDBJ
ABQ98918.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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