A5UDJ8 · NDK_HAEIE
- ProteinNucleoside diphosphate kinase
- Genendk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids140 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 58 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 86 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 92 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 103 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 113 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 116 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDK ; NDP kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionA5UDJ8
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000192258 | 1-140 | Nucleoside diphosphate kinase | |||
Sequence: MTERTFSIIKPDAVKRNLIGAILTRFEQNGFKIIASKMVRLTREQAEGFYAEHQGKEFFAPLVEYMMSSPIVVSVLEKENAVKDYRTLIGTTNPETAEEGTIRKDFALSQRENSVHGSDSIENANREIAYFFTDCEIFER |
Keywords
- PTM
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length140
- Mass (Da)16,021
- Last updated2007-07-10 v1
- Checksum03A24B71F5463D86
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000671 EMBL· GenBank· DDBJ | ABQ98849.1 EMBL· GenBank· DDBJ | Genomic DNA |