A5UBB1 · LIPB_HAEIE

Function

function

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site70-77substrate
Site135Lowers pKa of active site Cys
Binding site138-140substrate
Binding site151-153substrate
Active site169Acyl-thioester intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlipoyl(octanoyl) transferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Octanoyltransferase
  • EC number
  • Alternative names
    • Lipoate-protein ligase B
    • Lipoyl/octanoyl transferase
    • Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase

Gene names

    • Name
      lipB
    • Ordered locus names
      CGSHiEE_03175

Organism names

Accessions

  • Primary accession
    A5UBB1

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000011041-212Octanoyltransferase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-209BPL/LPL catalytic

Sequence similarities

Belongs to the LipB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    24,075
  • Last updated
    2007-07-10 v1
  • Checksum
    A66F2476EA746EE4
MNNSLIVRQLGLQDYQEIWHKMQDFTDTRNAETQDEIWLVQHYPVFTQGQAGKPEHLLQRSEIPVVQSDRGGQITYHAPGQQVMYVLIDIKRHKNLNVRQLVTALEQTVVKTLAEYGIESYPKPDAPGVYVDGKKICSLGLRIRRGCSFHGLALNINMDLNPFHYINPCGYAGLEMCQLADFVNQDEADCDNVSAKLIKHFADLLGYNITTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000671
EMBL· GenBank· DDBJ
ABQ98062.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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