A5U9Z9 · LUXS_HAEIE
- ProteinS-ribosylhomocysteine lyase
- GeneluxS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids167 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Catalytic activity
- S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine
Cofactor
Note: Binds 1 Fe cation per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | iron ion binding | |
Molecular Function | S-ribosylhomocysteine lyase activity | |
Biological Process | quorum sensing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-ribosylhomocysteine lyase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionA5U9Z9
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000004844 | 1-167 | S-ribosylhomocysteine lyase | |||
Sequence: MPLLDSFKVDHTKMNAPAVRIAKTMRTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGDSIEIIDISPMGCRTGFYMSLIGTPNEQEVSEAWLASMQDVLGVQDQASIPELNIYQCGSYTEHSLEDAHEIAKNVIARGIGVNKNEDLSLDNSLLK |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length167
- Mass (Da)18,571
- Last updated2007-07-10 v1
- Checksum14076FFED42389A6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000671 EMBL· GenBank· DDBJ | ABQ97600.1 EMBL· GenBank· DDBJ | Genomic DNA |