A5U9Z9 · LUXS_HAEIE

Function

function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 1 Fe cation per subunit.

Features

Showing features for binding site.

116720406080100120140160
TypeIDPosition(s)Description
Binding site54Fe cation (UniProtKB | ChEBI)
Binding site58Fe cation (UniProtKB | ChEBI)
Binding site128Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioniron ion binding
Molecular FunctionS-ribosylhomocysteine lyase activity
Biological Processquorum sensing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-ribosylhomocysteine lyase
  • EC number
  • Alternative names
    • AI-2 synthesis protein
    • Autoinducer-2 production protein LuxS

Gene names

    • Name
      luxS
    • Ordered locus names
      CGSHiEE_00530

Organism names

Accessions

  • Primary accession
    A5U9Z9

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000048441-167S-ribosylhomocysteine lyase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the LuxS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    18,571
  • Last updated
    2007-07-10 v1
  • Checksum
    14076FFED42389A6
MPLLDSFKVDHTKMNAPAVRIAKTMRTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGDSIEIIDISPMGCRTGFYMSLIGTPNEQEVSEAWLASMQDVLGVQDQASIPELNIYQCGSYTEHSLEDAHEIAKNVIARGIGVNKNEDLSLDNSLLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000671
EMBL· GenBank· DDBJ
ABQ97600.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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