A5U908 · CDS1_MYCTA
- ProteinL-cysteine desulfhydrase Cds1
- Genecds1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids368 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
A cysteine desulfhydrase that generates hydrogen sulfide, H2S. The H2S produced by this enzyme stimulates respiration in M.tuberculosis, mediated primarily via cytochrome bd with a lesser contribution from cytochrome bc1/aa3. H2S modulates the balance between respiration and glycolysis, and also contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress).
Miscellaneous
Has been modeled to bind the antibiotic bostrycin.
Catalytic activity
- L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4+ + H+This reaction proceeds in the forward direction.
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 203-207 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 299 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | lyase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | cysteine biosynthetic process | |
Biological Process | L-cysteine catabolic process to pyruvate |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-cysteine desulfhydrase Cds1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis complex
Accessions
- Primary accessionA5U908
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000456521 | 1-368 | L-cysteine desulfhydrase Cds1 | ||
Modified residue | 67 | N6-(pyridoxal phosphate)lysine | |||
Expression
Induction
Decreased expression following exposure to the antibiotic bostrycin (at protein level).
Structure
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)39,957
- Last updated2022-10-12 v2
- MD5 Checksum1AEC2B28CA52ACFA1779E6BEAB0D0DC0
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000611 EMBL· GenBank· DDBJ | ABQ75508.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |