A5PMY6 · COL12_DANRE
- ProteinCollectin-12
- Genecolec12
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids720 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 643 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 645 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 649 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 670 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 673 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 673 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 675 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 675 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 676 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 685 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 685 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 685 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 686 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 697 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 697 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 698 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 698 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 710 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen trimer | |
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular space | |
Cellular Component | membrane | |
Molecular Function | carbohydrate binding | |
Molecular Function | low-density lipoprotein particle binding | |
Molecular Function | metal ion binding | |
Molecular Function | pattern recognition receptor activity | |
Biological Process | phagocytosis, recognition | |
Biological Process | vasculogenesis |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCollectin-12
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA5PMY6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-37 | Cytoplasmic | ||||
Sequence: MKDDFNDEEEVQSFGYKRFGIQEGNECTKCKNDWALR | ||||||
Transmembrane | 38-58 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: VAIALLYVLCALLTIAVAVLG | ||||||
Topological domain | 59-720 | Extracellular | ||||
Sequence: YKVVQRMDNVTEGMQNYGGKITAVETDLKKLDDQTGEKSENATSELHSFKLEFQTLQKQLSDVIVKTSNNRAVLKELQLAGEDMQSGHLSLRDLLESNANVISKVNHTLNTYNSLIDGLKTETARLQSDLHVQTSEQGQNSHSISTLNFTQTQQRNLISSLQRSVEDTGQAVQKLKNDYQSLQQVARQTKADADWLREKVQNLQALAANNSLLTRSNSDSLEDVTSQLTTLSEQVQNTSTITDSHDQSLRELMDQQRDHDNATSIRFDALEARLDSNEGEMDRITGNVSFTTQLLRAISTDLNGLRTCSETVTRHSELLHGLNNSVAETRAESTELKAQQEELAVRLDKEVSSLSIVMDEMKLVDNKHSQLITNFTILQGPPGPRGPRGDKGSMGLPGKTGPKGEKGEKGAPGDAGPKGEKGPAGPPGVPGLKGPPGSRGSPGPKGSRGSGGRQGPSGEKGDPGIPGMPGRDGQPGPTGPQGPQGLRGPAGPAGLEGARGPVGPIGPPGPPGLPGLPAPPIVVPPVDPQGFVNRQVAPPPTTTPGCPPQWKGFREQCYHFSAPMESLNFDEAKERCSNLSSSMLIINDEEEQLWIKRQISGKGYFWLGLKWKPGQPDNWSHGHEAGEDCAGLIHEASWNDFFCTERIGFICERTNESKVPVL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000318685 | 1-720 | Collectin-12 | |||
Sequence: MKDDFNDEEEVQSFGYKRFGIQEGNECTKCKNDWALRVAIALLYVLCALLTIAVAVLGYKVVQRMDNVTEGMQNYGGKITAVETDLKKLDDQTGEKSENATSELHSFKLEFQTLQKQLSDVIVKTSNNRAVLKELQLAGEDMQSGHLSLRDLLESNANVISKVNHTLNTYNSLIDGLKTETARLQSDLHVQTSEQGQNSHSISTLNFTQTQQRNLISSLQRSVEDTGQAVQKLKNDYQSLQQVARQTKADADWLREKVQNLQALAANNSLLTRSNSDSLEDVTSQLTTLSEQVQNTSTITDSHDQSLRELMDQQRDHDNATSIRFDALEARLDSNEGEMDRITGNVSFTTQLLRAISTDLNGLRTCSETVTRHSELLHGLNNSVAETRAESTELKAQQEELAVRLDKEVSSLSIVMDEMKLVDNKHSQLITNFTILQGPPGPRGPRGDKGSMGLPGKTGPKGEKGEKGAPGDAGPKGEKGPAGPPGVPGLKGPPGSRGSPGPKGSRGSGGRQGPSGEKGDPGIPGMPGRDGQPGPTGPQGPQGLRGPAGPAGLEGARGPVGPIGPPGPPGLPGLPAPPIVVPPVDPQGFVNRQVAPPPTTTPGCPPQWKGFREQCYHFSAPMESLNFDEAKERCSNLSSSMLIINDEEEQLWIKRQISGKGYFWLGLKWKPGQPDNWSHGHEAGEDCAGLIHEASWNDFFCTERIGFICERTNESKVPVL | ||||||
Disulfide bond | 604↔615 | |||||
Sequence: CPPQWKGFREQC | ||||||
Disulfide bond | 634↔709 | |||||
Sequence: CSNLSSSMLIINDEEEQLWIKRQISGKGYFWLGLKWKPGQPDNWSHGHEAGEDCAGLIHEASWNDFFCTERIGFIC | ||||||
Disulfide bond | 687↔701 | |||||
Sequence: CAGLIHEASWNDFFC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 95-120 | |||||
Sequence: EKSENATSELHSFKLEFQTLQKQLSD | ||||||
Coiled coil | 216-267 | |||||
Sequence: ISSLQRSVEDTGQAVQKLKNDYQSLQQVARQTKADADWLREKVQNLQALAAN | ||||||
Coiled coil | 377-408 | |||||
Sequence: LHGLNNSVAETRAESTELKAQQEELAVRLDKE | ||||||
Region | 433-576 | Disordered | ||||
Sequence: FTILQGPPGPRGPRGDKGSMGLPGKTGPKGEKGEKGAPGDAGPKGEKGPAGPPGVPGLKGPPGSRGSPGPKGSRGSGGRQGPSGEKGDPGIPGMPGRDGQPGPTGPQGPQGLRGPAGPAGLEGARGPVGPIGPPGPPGLPGLPA | ||||||
Domain | 444-503 | Collagen-like 1 | ||||
Sequence: GPRGDKGSMGLPGKTGPKGEKGEKGAPGDAGPKGEKGPAGPPGVPGLKGPPGSRGSPGPK | ||||||
Domain | 510-569 | Collagen-like 2 | ||||
Sequence: GRQGPSGEKGDPGIPGMPGRDGQPGPTGPQGPQGLRGPAGPAGLEGARGPVGPIGPPGPP | ||||||
Compositional bias | 561-576 | Pro residues | ||||
Sequence: GPIGPPGPPGLPGLPA | ||||||
Domain | 611-710 | C-type lectin | ||||
Sequence: FREQCYHFSAPMESLNFDEAKERCSNLSSSMLIINDEEEQLWIKRQISGKGYFWLGLKWKPGQPDNWSHGHEAGEDCAGLIHEASWNDFFCTERIGFICE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length720
- Mass (Da)78,035
- Last updated2007-07-10 v1
- Checksum0DD184C27C37E0AC
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2BAJ9 | A0A8M2BAJ9_DANRE | colec12 | 740 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 80 | in Ref. 2; AAI24304 | ||||
Sequence: T → M | ||||||
Sequence conflict | 112 | in Ref. 2; AAI24304 | ||||
Sequence: Q → R | ||||||
Compositional bias | 561-576 | Pro residues | ||||
Sequence: GPIGPPGPPGLPGLPA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX927088 EMBL· GenBank· DDBJ | CAN88233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC124303 EMBL· GenBank· DDBJ | AAI24304.1 EMBL· GenBank· DDBJ | mRNA |