A5K8B0 · ENT1_PLAVS
- ProteinNucleoside transporter 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids416 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Nucleoside and nucleobase transporter with a broad substrate specificity.
Miscellaneous
In contrast to the human transporter SLC29A1, has low sensitivity to the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and dipyridamole.
Catalytic activity
- inosine(in) = inosine(out)This reaction proceeds in the backward direction.
- adenosine(in) = adenosine(out)This reaction proceeds in the backward direction.
- hypoxanthine(out) = hypoxanthine(in)
- guanosine(in) = guanosine(out)This reaction proceeds in the backward direction.
- guanine(out) = guanine(in)
- thymidine(in) = thymidine(out)This reaction proceeds in the backward direction.
- uridine(out) = uridine(in)
- uracil(in) = uracil(out)This reaction proceeds in the backward direction.
- thymine(out) = thymine(in)
- adenine(out) = adenine(in)
- cytosine(out) = cytosine(in)
- xanthine(out) = xanthine(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | nucleoside transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNucleoside transporter 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)
Accessions
- Primary accessionA5K8B0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-35 | Cytoplasmic | |||
Transmembrane | 36-58 | Helical | |||
Topological domain | 59-64 | Extracellular | |||
Transmembrane | 65-83 | Helical | |||
Topological domain | 84-87 | Cytoplasmic | |||
Transmembrane | 88-107 | Helical | |||
Topological domain | 108-119 | Extracellular | |||
Transmembrane | 120-139 | Helical | |||
Topological domain | 140-148 | Cytoplasmic | |||
Transmembrane | 149-171 | Helical | |||
Topological domain | 172-187 | Extracellular | |||
Transmembrane | 188-210 | Helical | |||
Topological domain | 211-241 | Cytoplasmic | |||
Transmembrane | 242-261 | Helical | |||
Topological domain | 262-273 | Extracellular | |||
Transmembrane | 274-292 | Helical | |||
Topological domain | 293-311 | Cytoplasmic | |||
Transmembrane | 312-331 | Helical | |||
Topological domain | 332-343 | Extracellular | |||
Transmembrane | 344-366 | Helical | |||
Topological domain | 367-380 | Cytoplasmic | |||
Transmembrane | 381-403 | Helical | |||
Topological domain | 404-416 | Extracellular | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 23 | no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain | |||
Natural variant | 99 | no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain; when associated with K-367 | |||
Natural variant | 178 | no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain | |||
Natural variant | 188 | no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain | |||
Natural variant | 329 | results in significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain | |||
Natural variant | 367 | no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain; when associated with I-99 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000461081 | 1-416 | Nucleoside transporter 1 | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-28 | Disordered | |||
Compositional bias | 9-28 | Basic and acidic residues | |||
Sequence similarities
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)47,009
- Last updated2007-07-10 v1
- ChecksumDFD7A189A6408C31
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 9-28 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAKM01000009 EMBL· GenBank· DDBJ | EDL44524.1 EMBL· GenBank· DDBJ | Genomic DNA |