A5K8B0 · ENT1_PLAVS

Function

function

Nucleoside and nucleobase transporter with a broad substrate specificity.

Miscellaneous

In contrast to the human transporter SLC29A1, has low sensitivity to the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and dipyridamole.

Catalytic activity

  • inosine(in) = inosine(out)
    This reaction proceeds in the backward direction.
  • adenosine(in) = adenosine(out)
    This reaction proceeds in the backward direction.
  • hypoxanthine(out) = hypoxanthine(in)
  • guanosine(in) = guanosine(out)
    This reaction proceeds in the backward direction.
  • guanine(out) = guanine(in)
  • thymidine(in) = thymidine(out)
    This reaction proceeds in the backward direction.
  • uridine(out) = uridine(in)
  • uracil(in) = uracil(out)
    This reaction proceeds in the backward direction.
  • thymine(out) = thymine(in)
  • adenine(out) = adenine(in)
  • cytosine(out) = cytosine(in)
  • xanthine(out) = xanthine(in)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionnucleoside transmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoside transporter 1
  • Alternative names
    • Equilibrative Nucleoside Transporter Type 1
      (PvENT1
      )

Gene names

    • ORF names
      PVX_083260

Organism names

  • Taxonomic identifier
  • Strain
    • Salvador I
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A5K8B0

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-35Cytoplasmic
Transmembrane36-58Helical
Topological domain59-64Extracellular
Transmembrane65-83Helical
Topological domain84-87Cytoplasmic
Transmembrane88-107Helical
Topological domain108-119Extracellular
Transmembrane120-139Helical
Topological domain140-148Cytoplasmic
Transmembrane149-171Helical
Topological domain172-187Extracellular
Transmembrane188-210Helical
Topological domain211-241Cytoplasmic
Transmembrane242-261Helical
Topological domain262-273Extracellular
Transmembrane274-292Helical
Topological domain293-311Cytoplasmic
Transmembrane312-331Helical
Topological domain332-343Extracellular
Transmembrane344-366Helical
Topological domain367-380Cytoplasmic
Transmembrane381-403Helical
Topological domain404-416Extracellular

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant23no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain
Natural variant99no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain; when associated with K-367
Natural variant178no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain
Natural variant188no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain
Natural variant329results in significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain
Natural variant367no significant growth defects in adenosine-dependent proliferation assay when transporter expressed in purine auxotrophic yeast strain; when associated with I-99

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004610811-416Nucleoside transporter 1

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-28Disordered
Compositional bias9-28Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    416
  • Mass (Da)
    47,009
  • Last updated
    2007-07-10 v1
  • Checksum
    DFD7A189A6408C31
MSISKESSKTMIDIEKKGGEGKDGKGGSKMTKNEQFLLPFTFILIGLSSLNVWNTALGLNINFKYNTFQITGLVCSSIIALFVKVPKMLLPFALGGLAMLCAGFQIAHQCFTFEQFDTYCLIAFIVIGIMAGLAQTIAFSVGTTMEENMGGYMSAGIGISGVFIFIINLLLDQIVPDQKKFNVNEAKLLYLFLICELCLVLAIIFSVCNLELSSSKTSKEEEYSDKEQGLSYLELLKDSYKAILAMFLVNWLSLQLFPGVGHKKWQESHNISDYNVTLIVGMFQVFDFVSRYPPNLSHMKIFKWFTFSLNKLLLLNFLRLLFIPWFVINAACDLPIFTNIVQQCVCMAMLAFTNGWFNTVPFLVFVQELKKAKKKKDIETISTFLVVAMFVGLFMGIWTTYIYDFFPIVIKRYVVP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias9-28Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAKM01000009
EMBL· GenBank· DDBJ
EDL44524.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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