A5K3F9 · NNRE_PLAVS
- ProteinNAD(P)H-hydrate epimerase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids289 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Catalytic activity
- (6R)-NADHX = (6S)-NADHX
Cofactor
Note: Binds 1 potassium ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 122-126 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: NNGGD | ||||||
Binding site | 123 | K+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 185 | K+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 189-195 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: GFSFTGE | ||||||
Binding site | 218 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 221 | K+ (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | NADHX epimerase activity | |
Molecular Function | NADPHX epimerase activity | |
Molecular Function | nucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H-hydrate epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)
Accessions
- Primary accessionA5K3F9
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416327 | 1-289 | NAD(P)H-hydrate epimerase | |||
Sequence: MRKELLLRTTNHSAFQNSVYLLGFLRFAKFQLSSRANISNVRPFKGRRTNCAATSVHSNRMEVTYLSQSLAQTIDNELMSDDVGYTTEQLMELAGLSIAQIICREYSLDRFKKVLIFCGPGNNGGDGLVAARHLKHFGYDVTVAYPKEKTKVLFQRLLKLLQHYHVPVVKSATGEDLKLYDLVVDALFGFSFTGEPRSPFDEIIHTINQSNKPVVSVDVPSGTNIDGGSAANALSVNSEMNISLMLPKEGVRHYGKKHYLGGRFIPNSIVEKYNLKVPQFAGDNSYVQL |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 71-277 | YjeF N-terminal | ||||
Sequence: AQTIDNELMSDDVGYTTEQLMELAGLSIAQIICREYSLDRFKKVLIFCGPGNNGGDGLVAARHLKHFGYDVTVAYPKEKTKVLFQRLLKLLQHYHVPVVKSATGEDLKLYDLVVDALFGFSFTGEPRSPFDEIIHTINQSNKPVVSVDVPSGTNIDGGSAANALSVNSEMNISLMLPKEGVRHYGKKHYLGGRFIPNSIVEKYNLKV |
Sequence similarities
Belongs to the NnrE/AIBP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length289
- Mass (Da)32,254
- Last updated2007-07-10 v1
- ChecksumCCD204CF3C49711D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAKM01000004 EMBL· GenBank· DDBJ | EDL46063.1 EMBL· GenBank· DDBJ | Genomic DNA |