A5JYX8 · NCLN_CAEEL
- ProteinNicalin
- Genenra-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids563 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER) (PubMed:19609303, PubMed:24567339).
In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER (PubMed:19609303).
Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR (PubMed:19609303).
Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions (PubMed:15990870, PubMed:19609303).
In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel (PubMed:24567339).
In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER (PubMed:19609303).
Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR (PubMed:19609303).
Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions (PubMed:15990870, PubMed:19609303).
In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel (PubMed:24567339).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Biological Process | protein-containing complex assembly | |
Biological Process | regulation of protein targeting to membrane | |
Biological Process | regulation of signal transduction |
Names & Taxonomy
Protein names
- Recommended nameNicalin
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionA5JYX8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Note: During the assembly of acetylcholine receptor in muscles, colocalizes with L-AChR component unc-29 in the ER.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 30-522 | Lumenal | ||||
Sequence: SQQVGEVVETEFHAYRLHQYEISGNIYGCKNYRVSYEAVSLGARTLRRTMVTTWRDLLTTDVDDMWALSTGAVLIFIPDNLDELNDIDRKAFIDLEAKLLSAKTDLAVYVAPFNDDAVSILHDVNTRSEKAPTALQHLLQSLSGNTISITSSDQSPELPPSYKPLNIVGRLSSGDRAAPTIAFVAHYDTQSAVPGVSPGADSNGSGIVALLELLAVLSKFYDSPSTRPPYNILFIWTAAGKLNYQGTRHWIDEYQKGFDSADYAKSGLSRKGFSDDRVDLAICIEAIGRKTGGFFMHAGKTPSENSVAAQLLRRLKYFSSISPKKNIELVTKKISLTTVSAWEHEKFNIKRMPAITLSTLPSPSDPARNSILDLPSALDEDELIDNIRLIGEAVLGYILDLPESGPSSDSRVKSEATMLSKDAVDKQRVHHFIRQFASRPRPVGDQRATESITSNLASVAAGYGNVFKSAVTITDAKAFGVTQNRLVAERVKP | ||||||
Transmembrane | 523-543 | Helical | ||||
Sequence: AVFELVIAAGVFTYLSAFYYI | ||||||
Topological domain | 544-563 | Cytoplasmic | ||||
Sequence: ATHSQNTIEGTVAAIRKSIF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MQDEIIDFFRSPALLFYMTLMLTICVVNG | ||||||
Chain | PRO_5002683601 | 30-563 | Nicalin | |||
Sequence: SQQVGEVVETEFHAYRLHQYEISGNIYGCKNYRVSYEAVSLGARTLRRTMVTTWRDLLTTDVDDMWALSTGAVLIFIPDNLDELNDIDRKAFIDLEAKLLSAKTDLAVYVAPFNDDAVSILHDVNTRSEKAPTALQHLLQSLSGNTISITSSDQSPELPPSYKPLNIVGRLSSGDRAAPTIAFVAHYDTQSAVPGVSPGADSNGSGIVALLELLAVLSKFYDSPSTRPPYNILFIWTAAGKLNYQGTRHWIDEYQKGFDSADYAKSGLSRKGFSDDRVDLAICIEAIGRKTGGFFMHAGKTPSENSVAAQLLRRLKYFSSISPKKNIELVTKKISLTTVSAWEHEKFNIKRMPAITLSTLPSPSDPARNSILDLPSALDEDELIDNIRLIGEAVLGYILDLPESGPSSDSRVKSEATMLSKDAVDKQRVHHFIRQFASRPRPVGDQRATESITSNLASVAAGYGNVFKSAVTITDAKAFGVTQNRLVAERVKPAVFELVIAAGVFTYLSAFYYIATHSQNTIEGTVAAIRKSIF | ||||||
Glycosylation | 232 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in body wall, pharyngeal, and vulval muscles, excretory canal cell, head and motor neurons, and vulval epithelium.
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
A5JYX8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length563
- Mass (Da)61,872
- Last updated2007-06-26 v1
- Checksum57887C9DCF452638
A5JYX8-2
- Namea
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284601 EMBL· GenBank· DDBJ | CAB04692.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284601 EMBL· GenBank· DDBJ | CAN86915.1 EMBL· GenBank· DDBJ | Genomic DNA |