A5JS51 · A5JS51_9TRYP

  • Protein
    Variant surface glycoprotein
  • Gene
    VSG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Biological Processevasion of host immune response

Names & Taxonomy

Protein names

  • Submitted names
    • Variant surface glycoprotein

Gene names

    • Name
      VSG

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A5JS51

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_500268350818-519

Keywords

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region.

Type
IDPosition(s)Description
Domain14-371Trypanosome variant surface glycoprotein A-type N-terminal
Coiled coil371-398
Domain404-518Trypanosome variant surface glycoprotein C-terminal
Compositional bias443-458Polar residues
Region443-482Disordered
Compositional bias460-482Basic and acidic residues

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    519
  • Mass (Da)
    55,753
  • Last updated
    2007-06-26 v1
  • Checksum
    B68DF9D65CFAD890
MHFAIFLLSPLYATVMATHEALKETHWGPVCELAGELNKLPGAARAKLKALRSAEQAARVTALQLNVYAAMQKNNKSAAAIGALAAAVGAQAKAARAALDAKTSEFVRATATTSHFAGAVGEAINFLDKIAGTGGTFYCLGNTNAGAAGNSQINAQGCVPTSWQYAEEDTKLKDRTYDGTSFPKLKDISGTSAKGGTASKCGLFQFGADQNDPIITASRPTLAAGLMQPTATDTISMATIGDLTTKQRETETSRLKAVHHDTKTIADFTTADYKTEPEKIIEAAITSSKAADMLKQMLKATYSPEHSKQAEALAEEIAKAIYKPDDDKGKSIWNELKAAKPRTVAGDDSKQAGLHTISDEDTLHRLLAYYTQSALDNVAAKELELHKLKNELADQKGKSPEAECNKLESTEKCNEENICSWHKEVKTGEKNCQFNSTKAKEKGVTVTQTQTGGDGTTAPSDRCTRHKDKPNCEKENEGQKPGEKAKCGWIEEKCRDSSFLLNKQFALSMVSAAFVALLF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias443-458Polar residues
Compositional bias460-482Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF560194
EMBL· GenBank· DDBJ
ABQ52438.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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