A5IYB2 · TSAD_MYCAP

Function

function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site108Fe cation (UniProtKB | ChEBI)
Binding site112Fe cation (UniProtKB | ChEBI)
Binding site130-134substrate
Binding site163substrate
Binding site176substrate
Binding site180substrate
Binding site269substrate
Binding site293Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioniron ion binding
Molecular FunctionN(6)-L-threonylcarbamoyladenine synthase activity
Biological ProcesstRNA threonylcarbamoyladenosine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA N6-adenosine threonylcarbamoyltransferase
  • EC number
  • Alternative names
    • N6-L-threonylcarbamoyladenine synthase
      (t(6)A synthase
      )
    • t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD
    • tRNA threonylcarbamoyladenosine biosynthesis protein TsaD

Gene names

    • Name
      tsaD
    • Synonyms
      gcp
    • Ordered locus names
      MAG3230

Organism names

Accessions

  • Primary accession
    A5IYB2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001459991-309tRNA N6-adenosine threonylcarbamoyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the KAE1 / TsaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    34,291
  • Last updated
    2007-06-26 v1
  • MD5 Checksum
    C69330BAD9B3AA925A10DC6395FF309E
MKILGIETSHDDTSIAILENNKVVALETISQVDIFKEFGGTIPEISSREHVKNINLILEILIKKHDLSTIDYVAYTKEPGLVGTLQIGYLFANAVSLAYNKPIIPINHLAGHFYSCAIDHEINYPSLCLLVSGGHTQLMLINNPNDFQIIGQTLDDAVGEAFDKVSSKLQLGFPGGPIIDKIYKNYNGEFIKFTEPHAPGEYNFSFSGLKSQVINYYHNKIQRNEAIDINQIAASFQDCAVSYLINQTKKALRKYNVKSLVLAGGVSANSELRKRFLEISNIAIIPDLKYATDNGAMIASCAYQMLKEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU179680
EMBL· GenBank· DDBJ
CAL59021.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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