A5IL77 · NFI_THEP1

Function

function

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

Catalytic activity

  • Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.
    EC:3.1.21.7 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

122520406080100120140160180200220
TypeIDPosition(s)Description
Binding site43Mg2+ (UniProtKB | ChEBI)
Site80Interaction with target DNA
Binding site110Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondeoxyribonuclease V activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease V
  • EC number
  • Alternative names
    • Deoxyinosine 3'endonuclease
    • Deoxyribonuclease V
      (DNase V
      )

Gene names

    • Name
      nfi
    • Ordered locus names
      Tpet_0932

Organism names

Accessions

  • Primary accession
    A5IL77

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000470051-225Endonuclease V

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the endonuclease V family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,612
  • Last updated
    2007-06-26 v1
  • Checksum
    84250E644DF93FD5
MDYRQLHRWDLPPEEAIKVQNELRKKIKLTPYEGEPEYVAGVDLSFPGKEEGLAVIVVLEYPSFKILEVVSERGEITFPYIPGLLAFREGPLFLKAWEKLRTKPDVVVFDGQGLAHPRKLGIASHMGLFIEIPTIGVAKSRLYGTFKMPEDKRCSWSYLYDGEEIIGCVIRTKEGSAPIFVSPGHLMDIESSKRLIKAFTLPGRRIPEPTRLAHIYTQRLKKGLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000702
EMBL· GenBank· DDBJ
ABQ46950.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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