A5IAU5 · AMPA_LEGPC
- ProteinProbable cytosol aminopeptidase
- GenepepA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids483 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Catalytic activity
- Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 252 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 257 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 257 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 264 | |||||
Sequence: K | ||||||
Binding site | 275 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 334 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 336 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 336 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 338 | |||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | manganese ion binding | |
Molecular Function | metalloaminopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProbable cytosol aminopeptidase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella
Accessions
- Primary accessionA5IAU5
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000203833 | 1-483 | Probable cytosol aminopeptidase | |||
Sequence: MNYGLTHTPSLTMSECLVLGVFSDLALPDFATAIDNEQKGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQCGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLNQESAEWQLEQMIVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLEMAKAIVTGVEFCRDLANMPANICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHGNKNSTPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVANSR |
Structure
Sequence
- Sequence statusComplete
- Length483
- Mass (Da)52,613
- Last updated2007-06-26 v1
- Checksum695CC2F46D38ACE6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000675 EMBL· GenBank· DDBJ | ABQ54495.1 EMBL· GenBank· DDBJ | Genomic DNA |