A5IAU5 · AMPA_LEGPC

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site252Mn2+ 2 (UniProtKB | ChEBI)
Binding site257Mn2+ 1 (UniProtKB | ChEBI)
Binding site257Mn2+ 2 (UniProtKB | ChEBI)
Active site264
Binding site275Mn2+ 2 (UniProtKB | ChEBI)
Binding site334Mn2+ 1 (UniProtKB | ChEBI)
Binding site336Mn2+ 1 (UniProtKB | ChEBI)
Binding site336Mn2+ 2 (UniProtKB | ChEBI)
Active site338

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • Ordered locus names
      LPC_0510

Organism names

Accessions

  • Primary accession
    A5IAU5

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002038331-483Probable cytosol aminopeptidase

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    483
  • Mass (Da)
    52,613
  • Last updated
    2007-06-26 v1
  • Checksum
    695CC2F46D38ACE6
MNYGLTHTPSLTMSECLVLGVFSDLALPDFATAIDNEQKGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQCGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLNQESAEWQLEQMIVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLEMAKAIVTGVEFCRDLANMPANICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHGNKNSTPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVANSR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000675
EMBL· GenBank· DDBJ
ABQ54495.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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