A5I6W9 · A5I6W9_CLOBH

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

139650100150200250300350
TypeIDPosition(s)Description
Binding site58Zn2+ 1 (UniProtKB | ChEBI)
Binding site60Zn2+ 1 (UniProtKB | ChEBI)
Binding site60-62substrate
Binding site92substrate
Binding site149Zn2+ 1 (UniProtKB | ChEBI)
Binding site149Zn2+ 2 (UniProtKB | ChEBI)
Binding site176Zn2+ 2 (UniProtKB | ChEBI)
Binding site213Zn2+ 2 (UniProtKB | ChEBI)
Binding site253substrate
Active site280
Binding site280Zn2+ 1 (UniProtKB | ChEBI)
Binding site284substrate
Binding site294-295substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • Ordered locus names
      CBO3239

Organism names

Accessions

  • Primary accession
    A5I6W9
  • Secondary accessions
    • A7G854

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-391Amidohydrolase-related

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    44,626
  • Last updated
    2007-06-26 v1
  • Checksum
    BB5E0FD209158EE4
MNELLIKNVNIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFRDPGFTYKEDILTGSRAAVKGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLIEAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTDCKVHIAHVSTKESMEYIKNAKKKGLKVTCEVAPHHIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLSKLSKIMSKNPADILGVNNGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMYLKGRIKVTFKAGCIVYSEF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM412317
EMBL· GenBank· DDBJ
CAL84801.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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