A5I5S5 · A5I5S5_CLOBH
- ProteinMultidrug export protein MepA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids456 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Multidrug efflux pump.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | monoatomic ion transport | |
Biological Process | response to antibiotic |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMultidrug export protein MepA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA5I5S5
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-42 | Helical | ||||
Sequence: LSIPGIIGMLVIGLYNLCDAIFV | ||||||
Transmembrane | 62-83 | Helical | ||||
Sequence: FINNCIAVLVGVGSSSILSRAI | ||||||
Transmembrane | 95-117 | Helical | ||||
Sequence: LANLILSVLVLSLTVTVLGCFFS | ||||||
Transmembrane | 137-158 | Helical | ||||
Sequence: YLRIVYIGSFFVNFSQSANMLI | ||||||
Transmembrane | 170-189 | Helical | ||||
Sequence: IMALGAVLNIILDPIFIKTL | ||||||
Transmembrane | 195-217 | Helical | ||||
Sequence: GAAIATVIAQIIQALVTFMYFKC | ||||||
Transmembrane | 229-251 | Helical | ||||
Sequence: FAFDLMPEILSVGGSAAMMQLMY | ||||||
Transmembrane | 271-292 | Helical | ||||
Sequence: LVLMGVALRILMFTFIPIWGIG | ||||||
Transmembrane | 313-333 | Helical | ||||
Sequence: DAVKIFSIASTIFIGVLWGFY | ||||||
Transmembrane | 357-378 | Helical | ||||
Sequence: FFRLMFLTFPVSGLIVMSMTFF | ||||||
Transmembrane | 390-410 | Helical | ||||
Sequence: ITVLKQVILFMPIAIILTKII | ||||||
Transmembrane | 416-436 | Helical | ||||
Sequence: WLASSVTDAIVFVLSFVLLAI |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length456
- Mass (Da)49,980
- Last updated2007-06-26 v1
- ChecksumB6804E990EB08314
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM412317 EMBL· GenBank· DDBJ | CAL84403.1 EMBL· GenBank· DDBJ | Genomic DNA |