A5I1T8 · A5I1T8_CLOBH

Function

function

Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site167Mg2+ (UniProtKB | ChEBI)
Binding site227Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionphospho-N-acetylmuramoyl-pentapeptide-transferase activity
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Molecular FunctionUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Biological Processcell division
Biological Processcell wall macromolecule biosynthetic process
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
  • EC number
  • Alternative names
    • UDP-MurNAc-pentapeptide phosphotransferase

Gene names

    • Name
      mraY2
    • Synonyms
      mraY
      , murX2
    • Ordered locus names
      CBO1459

Organism names

Accessions

  • Primary accession
    A5I1T8
  • Secondary accessions
    • A7G3J5

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-26Helical
Transmembrane47-70Helical
Transmembrane76-96Helical
Transmembrane108-127Helical
Transmembrane147-168Helical
Transmembrane199-216Helical
Transmembrane223-244Helical
Transmembrane250-271Helical
Transmembrane298-316Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    317
  • Mass (Da)
    34,187
  • Last updated
    2007-06-26 v1
  • Checksum
    6B8A7CC531DD1B23
MNRIVYAVLLAFLISILGGPILIPLLHKFKFGQNIREEGPESHRKKAGTPTMGGVIFILSSIITMALTIRRPGDEAMVALYAFIAFGIIGALDDGLKIIHKNNLGLRAYQKMLLILVVSGIFGYYSANNPNIGTSIIMPFTRKSLDLGAFYIPGIIIYFAATTNAVNLTDGLDGLATSVTLLVMTFFALVSFGMGHYTLAIFCAVVAGALLGFLRYNAFPAQVFMGDTGSLALGGAVAAVAMILKLEILVIIVGGIYVLETLSVIIQVLSFKLTGKRVFKMSPIHHHFELSGWHETKVVSVFSIITVILCLVAFLAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM412317
EMBL· GenBank· DDBJ
CAL83002.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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