A5I1T8 · A5I1T8_CLOBH
- ProteinPhospho-N-acetylmuramoyl-pentapeptide-transferase
- GenemraY2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids317 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Catalytic activity
- UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
Cofactor
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | phospho-N-acetylmuramoyl-pentapeptide-transferase activity | |
Molecular Function | phosphotransferase activity, for other substituted phosphate groups | |
Molecular Function | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity | |
Biological Process | cell division | |
Biological Process | cell wall macromolecule biosynthetic process | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospho-N-acetylmuramoyl-pentapeptide-transferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA5I1T8
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-26 | Helical | ||||
Sequence: YAVLLAFLISILGGPILIPLL | ||||||
Transmembrane | 47-70 | Helical | ||||
Sequence: AGTPTMGGVIFILSSIITMALTIR | ||||||
Transmembrane | 76-96 | Helical | ||||
Sequence: AMVALYAFIAFGIIGALDDGL | ||||||
Transmembrane | 108-127 | Helical | ||||
Sequence: AYQKMLLILVVSGIFGYYSA | ||||||
Transmembrane | 147-168 | Helical | ||||
Sequence: LGAFYIPGIIIYFAATTNAVNL | ||||||
Transmembrane | 199-216 | Helical | ||||
Sequence: LAIFCAVVAGALLGFLRY | ||||||
Transmembrane | 223-244 | Helical | ||||
Sequence: VFMGDTGSLALGGAVAAVAMIL | ||||||
Transmembrane | 250-271 | Helical | ||||
Sequence: VIIVGGIYVLETLSVIIQVLSF | ||||||
Transmembrane | 298-316 | Helical | ||||
Sequence: VVSVFSIITVILCLVAFLA |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length317
- Mass (Da)34,187
- Last updated2007-06-26 v1
- Checksum6B8A7CC531DD1B23
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM412317 EMBL· GenBank· DDBJ | CAL83002.1 EMBL· GenBank· DDBJ | Genomic DNA |