A5HWA8 · EFL2_CAEEL

  • Protein
    Transcription factor efl-2
  • Gene
    efl-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Transcription activator (By similarity).
May activate expression of the pro-apoptotic genes ced-4 and ced-3 (PubMed:17881492).
Required for constitutive, and for DNA damage-induced, programmed cell death of germ cells (PubMed:17881492).

Features

Showing features for dna binding.

135850100150200250300350
TypeIDPosition(s)Description
DNA binding36-99

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentRb-E2F complex
Cellular ComponentRNA polymerase II transcription regulator complex
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processregulation of apoptotic process
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor efl-2
  • Alternative names
    • E2F-like family member 2

Gene names

    • Name
      efl-2
    • ORF names
      Y48C3A.17

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    A5HWA8
  • Secondary accessions
    • A5HWA6
    • Q9BIE8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced level of constitutive germ cell apoptosis on a ced-6 mutant background, in hermaphrodites (PubMed:17881492).
Blocks DNA damage-induced germ cell apoptosis, but does not affect associated cell-cycle arrest (PubMed:17881492).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004522491-358Transcription factor efl-2

Expression

Gene expression databases

Interaction

View interactors in UniProtKB
View CPX-1145 in Complex Portal

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Region1-31Disordered
Region331-358Disordered

Sequence similarities

Belongs to the E2F/DP family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

A5HWA8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    358
  • Mass (Da)
    39,759
  • Last updated
    2007-06-26 v1
  • Checksum
    C1B01ACB88B3329A
MDPSSIDLGSIPGGSEQQQHEDGAAAAAGSPKEVFRSQQSLGLITQRFMSLRQRNEVLNLNEVAKELNISKRRVYDVINVLEGLGYVEKVEKNNIRWIGDNNNSEEQNALEARVEMLRQQEKLLELMIRDAQAIIELHFEDPIERPYNYVSKEDIRKTAEPNTKSIIVKSELDTSSSFEIQVTDPSTSGSHDMIVRNKNGVKSHALLFTNDPPEYGDEEDEDDVKKLSSQKRFETSEALRVTLAEMLTDPTTISSSPKHIKLEEPEEIDTEDLETFVLPPSTSASQSNAPYLPETPGRGLFFSPFKSLIDPCILPSFSDDLTSGYINITTPSRATGAGAGASGQEDEEPVSVMDFFSD

A5HWA8-2

  • Name
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence AAK19023.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Alternative sequenceVSP_060929274-284in isoform b
Alternative sequenceVSP_060930285-358in isoform b

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY028167
EMBL· GenBank· DDBJ
AAK19023.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BX284602
EMBL· GenBank· DDBJ
CAN86629.1
EMBL· GenBank· DDBJ
Genomic DNA
BX284602
EMBL· GenBank· DDBJ
CAN86631.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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