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A5H0C9 · A5H0C9_WOLPM

  • Protein
    Uroporphyrinogen decarboxylase
  • Gene
    hemE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.

Features

Showing features for binding site, site.

133850100150200250300
Type
IDPosition(s)Description
Binding site27-31substrate
Binding site77substrate
Site77Transition state stabilizer
Binding site151substrate
Binding site203substrate
Binding site317substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionuroporphyrinogen decarboxylase activity
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uroporphyrinogen decarboxylase
  • EC number
  • Short names
    UPD
    ; URO-D

Gene names

    • Name
      hemE

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • WMel
    • WMelPop
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Wolbachieae > Wolbachia

Accessions

  • Primary accession
    A5H0C9

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-31Uroporphyrinogen decarboxylase (URO-D)
Domain139-155Uroporphyrinogen decarboxylase (URO-D)

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    338
  • Mass (Da)
    37,843
  • Last updated
    2007-06-12 v1
  • MD5 Checksum
    5351A41051299B96C82E2E483F7A78BE
MESGKTTIAKIIKRNEPGGRVPIWLMRQAGRSLPEYRKAVENMNNFMEICYNTDLVTELTLQPVTRFDMDAAIIFSDILIIADVLGCDVNFVRGVGPIIKPVESPKELKGPQEIETKTLPILNAIKKVRSQLPKEKSLIGFAGGPWTVASYIIEGRSSKTFSKVLNFYPSCLKEIIERITEVTIIYLIKQIEFGADVIQLFDSNAGALSEPLFKEYVIEPTKRIILAIKDRFSDFPIIGFPRSAGNLYKDYCEQTGVSAVSIDYNVPIKWAKANLNIPLQGNLDPNLLAYNKTEAIKEAKRIIDCFRDLPFIFNLGHGVLPDTPVENIAALVNLVKSY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ498878
EMBL· GenBank· DDBJ
ABF55503.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ498879
EMBL· GenBank· DDBJ
ABF55505.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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