A5EN81 · GMHA_BRASB

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site55-57substrate
Binding site64Zn2+ (UniProtKB | ChEBI)
Binding site68substrate
Binding site68Zn2+ (UniProtKB | ChEBI)
Binding site97-98substrate
Binding site123-125substrate
Binding site128substrate
Binding site175substrate
Binding site175Zn2+ (UniProtKB | ChEBI)
Binding site183Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA
    • Ordered locus names
      BBta_5671

Organism names

Accessions

  • Primary accession
    A5EN81

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000090531-198Phosphoheptose isomerase

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-198SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    20,498
  • Last updated
    2007-06-12 v1
  • Checksum
    D0BE5D2A5738A61C
MNRAADDLIASHLARSHAAMARAAQDTALLASAGRIAAKIVTALRSGRKLLIVGNGGSAADAQHIAAEIVGRYKQERPAFAAIALTTDTSALTAIGNDYGFDHVFARQVEGLGTSGDVLLAISTSGRSPSILNALRKARERGLTTIGFTGANGLAMGELCDELLVAPSDDTPLIQQIHLATAHGICETIEAALMQDLS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000494
EMBL· GenBank· DDBJ
ABQ37625.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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