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A5EKB0 · TIG_BRASB

Function

function

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Molecular Functionprotein folding chaperone
Molecular Functionribosome binding
Biological Process'de novo' cotranslational protein folding
Biological Processcell division
Biological Processchaperone-mediated protein folding
Biological Processprotein transport
Biological Processprotein unfolding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Trigger factor
  • EC number
  • Short names
    TF
  • Alternative names
    • PPIase

Gene names

    • Name
      tig
    • Ordered locus names
      BBta_4575

Organism names

Accessions

  • Primary accession
    A5EKB0

Proteomes

Subcellular Location

Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000226491-452Trigger factor

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain171-256PPIase FKBP-type

Domain

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.

Sequence similarities

Belongs to the FKBP-type PPIase family. Tig subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    452
  • Mass (Da)
    50,179
  • Last updated
    2007-06-12 v1
  • MD5 Checksum
    07D889EF109EBDC0E61BCE4FD8A682D9
MQVTETLSEGLKHEFQVSVPAADLDAKADAKLVDLKDKVRINGFRPGKVPVAHLKKIYGKSVMAETIDQTIRDTNTQIFTERGFRLATEPKVTMPTEEAEVEKILSGQSDLTYTVAVEVVPAITLADFKTFSVEKPVADITDADVDEAIKRLADANRSYAAKAEGAKAESGDRVKVNFKGTIDGVAFDGGTGEGIDVVIGSNTFIPGFEDQLIGIGVGETRTLKVAFPKNYLNNDLAGKDAEFETTATAIETPEEKVVDDEFAKTLGLESLDKLKQLMRDRLAGEFNQATRQRVKRALLDRLDETHKFDAPPSLIDEEFNLMWNSVKAEMDSSGKTFADENTTEEKAKEEYRTIADRRVRLGLVLSEIGEKNKITVTDDEVSRAVIERARSMPGREKEVWDFYRSNPQALAQLRAPIYEDKVVDFILELANVTEKKVSKDELFKDDENDKAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000494
EMBL· GenBank· DDBJ
ABQ36604.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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