A5D8W8 · A5D8W8_HUMAN
- ProteinGlutathione hydrolase
- GeneGGT7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids662 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 206 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 491-493 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 514 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 566 | L-glutamate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | acyltransferase activity | |
Molecular Function | glutathione hydrolase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA5D8W8
PTM/Processing
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length662
- Mass (Da)70,445
- Last updated2007-06-12 v1
- Checksum3A9A5759FA54AC5A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 66-82 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC141843 EMBL· GenBank· DDBJ | AAI41844.1 EMBL· GenBank· DDBJ | mRNA |