A5D8W8 · A5D8W8_HUMAN

  • Protein
    Glutathione hydrolase
  • Gene
    GGT7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site206L-glutamate (UniProtKB | ChEBI)
Binding site491-493L-glutamate (UniProtKB | ChEBI)
Binding site514L-glutamate (UniProtKB | ChEBI)
Binding site566L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionacyltransferase activity
Molecular Functionglutathione hydrolase activity
Biological Processglutathione catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • Name
      GGT7

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A5D8W8

Subcellular Location

Membrane
; Single-pass membrane protein
Membrane
; Single-pass type II membrane protein

PTM/Processing

Keywords

Proteomic databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region26-90Disordered
Compositional bias66-82Polar residues

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    662
  • Mass (Da)
    70,445
  • Last updated
    2007-06-12 v1
  • Checksum
    3A9A5759FA54AC5A
MAAENEASQESALGAYSPVDYMSITSLPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDSFLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATGVTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAVALCLGIVAPHSSGLGGGGVMLVHVIRRNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARALAEQLPPNMSERFRETFLPSGRPPLPGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGAPTAAQVLIMGPDDFIVAMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGATIL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias66-82Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC141843
EMBL· GenBank· DDBJ
AAI41844.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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